| 9/3/2021 | Salisbury | 56 | at | Albright | 14 | @ MidAC | ||
| Delaware Valley | 57 | at | Kean | 6 | MidAC | |||
| 9/4/2021 | Washington and Lee | 24 | at | Christopher Newport | 28 | ODC | ||
| New Jersey | 0 | at | Muhlenberg | 41 | @ Cen | |||
| Widener | 27 | at | Rowan | 22 | MidAC | |||
| Montclair State | 20 | at | Rensselaer | 21 | @ LL | |||
| William Paterson | 21 | at | Western Connecticut | 24 | @ MSCAC | |||
| 9/11/2021 | Christopher Newport | 27 | at | Averett | 30 | OT | @ ODC | |
| Montclair State | 2 | at | Delaware Valley | 26 | @ MidAC | |||
| Utica | 27 | at | Kean | 7 | E8 | |||
| Cortland | 49 | at | New Jersey | 6 | E8 | |||
| Springfield | 46 | at | Rowan | 24 | NEWMAC | |||
| Wisconsin-Whitewater | 31 | at | Salisbury | 14 | WIAC | |||
| Fairleigh Dickinson-Florham | 43 | at | William Paterson | 17 | MidAC | |||
| 9/18/2021 | Ferrum | 26 | at | Christopher Newport | 19 | ODC | ||
| William Paterson | 42 | at | Keystone | 14 | @ ECFC | |||
| Salve Regina | 24 | at | Montclair State | 21 | CCF | |||
| 9/25/2021 | Christopher Newport | 31 | at | Catholic | 14 | @ NEWMAC | ||
| Kean | 7 | at | Merchant Marine | 56 | @ NEWMAC | |||
| Worcester Polytechnic | 10 | at | Montclair State | 31 | NEWMAC | |||
| New Jersey | 31 | at | Nichols | 0 | @ CCF | |||
| Western New England | 14 | at | Salisbury | 40 | CCF | |||
| Rowan | 35 | at | Salve Regina | 50 | @ CCF | |||
| SUNY-Maritime | 7 | at | William Paterson | 28 | ECFC | |||
| 10/2/2021 | Kean | 27 | at | Christopher Newport | 20 | OT | ||
| Salisbury | 27 | at | Montclair State | 7 | ||||
| William Paterson | 14 | at | New Jersey | 15 | ||||
| 10/9/2021 | Rowan | 17 | at | Kean | 24 | |||
| New Jersey | 14 | at | Montclair State | 9 | ||||
| Christopher Newport | 28 | at | William Paterson | 48 | ||||
| 10/16/2021 | Montclair State | 0 | at | Christopher Newport | 28 | |||
| New Jersey | 7 | at | Kean | 20 | ||||
| Salisbury | 24 | at | Rowan | 7 | ||||
| 10/23/2021 | Christopher Newport | 21 | at | New Jersey | 14 | |||
| William Paterson | 10 | at | Rowan | 25 | ||||
| Kean | 6 | at | Salisbury | 38 | ||||
| 10/30/2021 | Salisbury | 84 | at | Christopher Newport | 14 | |||
| Rowan | 7 | at | Montclair State | 20 | ||||
| Kean | 6 | at | William Paterson | 20 | ||||
| 11/6/2021 | Christopher Newport | 35 | at | Rowan | 32 | |||
| New Jersey | 23 | at | Salisbury | 37 | ||||
| Montclair State | 23 | at | William Paterson | 22 | ||||
| 11/12/2021 | Rowan | 35 | at | New Jersey | 21 | |||
| 11/13/2021 | Montclair State | 7 | at | Kean | 15 | |||
| William Paterson | 7 | at | Salisbury | 38 | ||||
| 11/20/2021 | Johns Hopkins | 45 | at | Salisbury | 20 | Cen |