| 9/3/2021 | Westfield State (1-9) | 6 | at | Nichols | 21 | MSCAC | ||
| 9/11/2021 | Nichols | 27 | at | Anna Maria (7-3) | 23 | at ECFC | ||
| 9/18/2021 | Nichols | 6 | at | Coast Guard (2-8) | 33 | at NEWMAC | ||
| 9/25/2021 | New Jersey (3-6) | 31 | at | Nichols | 0 | NJAC | ||
| 10/2/2021 | Nichols | 19 | at | University of New England (4-5,2-4) | 28 | |||
| 10/16/2021 | Salve Regina (8-2,4-2) | 35 | at | Nichols | 20 | |||
| 10/23/2021 | Nichols | 0 | at | Western New England (7-4,5-1) | 49 | |||
| 10/30/2021 | Husson (7-3,4-2) | 14 | at | Nichols | 12 | |||
| 11/6/2021 | Nichols | 14 | at | Curry (3-6,1-5) | 28 | |||
| 11/13/2021 | Endicott (8-3,5-1) | 37 | at | Nichols | 3 |
| vs Nichols | vs Other Opponents | Nichols compared to OOs | |
| Record: | 8-2 | 42-47 | |
| Points Scored: | 28.40 | 21.94 | -6.46 |
| Points Allowed: | 12.20 | 25.74 | -13.54 |
| Margin: | 16.20 | -3.80 | -20.00 |
| Total Points: | 40.60 | 47.68 | -7.08 |