| 9/4/2021 | Springfield | 13 | at | Western New England (7-4) | 24 | at CCF | ||
| 9/11/2021 | Springfield | 46 | at | Rowan (2-7) | 24 | at NJAC | ||
| 9/18/2021 | Springfield | 23 | at | Union NY (8-2) | 30 | at LL | ||
| 9/25/2021 | Springfield | 21 | at | Husson (7-3) | 26 | at CCF | ||
| 10/9/2021 | Coast Guard (2-8,0-6) | 0 | at | Springfield | 60 | |||
| 10/16/2021 | Springfield | 56 | at | Norwich (2-8,1-5) | 7 | |||
| 10/23/2021 | Springfield | 46 | at | Worcester Polytechnic (3-7,2-4) | 17 | |||
| 10/30/2021 | Merchant Marine (9-1,5-1) | 23 | at | Springfield | 28 | |||
| 11/6/2021 | Springfield | 17 | at | MIT (5-4,3-3) | 7 | |||
| 11/13/2021 | Catholic (6-4,4-2) | 14 | at | Springfield | 28 | |||
| 11/20/2021 | Springfield | 21 | at | Cortland (11-1) | 26 | at E8 |
| vs Springfield | vs Other Opponents | Springfield compared to OOs | |
| Record: | 4-7 | 58-42 | |
| Points Scored: | 18.00 | 28.77 | 10.77 |
| Points Allowed: | 32.64 | 21.27 | 11.37 |
| Margin: | -14.64 | 7.50 | 22.14 |
| Total Points: | 50.64 | 50.04 | 0.60 |