| 9/3/2021 | Salve Regina | 38 | at | Norwich (2-8) | 0 | at NEWMAC | ||
| 9/11/2021 | MIT (5-4) | 16 | at | Salve Regina | 21 | NEWMAC | ||
| 9/18/2021 | Salve Regina | 24 | at | Montclair State (3-7) | 21 | at NJAC | ||
| 9/25/2021 | Rowan (2-7) | 35 | at | Salve Regina | 50 | NJAC | ||
| 10/2/2021 | Salve Regina | 3 | at | Western New England (7-4,5-1) | 41 | |||
| 10/9/2021 | University of New England (4-5,2-4) | 6 | at | Salve Regina | 48 | |||
| 10/16/2021 | Salve Regina | 35 | at | Nichols (2-8,0-6) | 20 | |||
| 10/23/2021 | Endicott (8-3,5-1) | 14 | at | Salve Regina | 21 | |||
| 10/30/2021 | Curry (3-6,1-5) | 14 | at | Salve Regina | 47 | |||
| 11/6/2021 | Salve Regina | 10 | at | Husson (7-3,4-2) | 24 |
| vs Salve Regina | vs Other Opponents | Salve Regina compared to OOs | |
| Record: | 2-8 | 41-47 | |
| Points Scored: | 19.10 | 21.52 | 2.42 |
| Points Allowed: | 29.70 | 23.88 | 5.82 |
| Margin: | -10.60 | -2.36 | 8.24 |
| Total Points: | 48.80 | 45.40 | 3.40 |