| 9/3/2021 | Merchant Marine | 49 | at | Fairleigh Dickinson-Florham | 27 | @ MidAC | ||
| Salve Regina | 38 | at | Norwich | 0 | CCF | |||
| Worcester State | 20 | at | Worcester Polytechnic | 38 | MSCAC | |||
| 9/4/2021 | McDaniel | 7 | at | Catholic | 40 | Cen | ||
| Curry | 7 | at | MIT | 41 | CCF | |||
| Coast Guard | 16 | at | University of New England | 0 | @ CCF | |||
| Springfield | 13 | at | Western New England | 24 | @ CCF | |||
| 9/10/2021 | Worcester Polytechnic | 21 | at | Endicott | 28 | @ CCF | ||
| 9/11/2021 | Coast Guard | 18 | at | Curry | 21 | @ CCF | ||
| Catholic | 10 | at | Randolph-Macon | 62 | @ ODC | |||
| Springfield | 46 | at | Rowan | 24 | @ NJAC | |||
| MIT | 16 | at | Salve Regina | 21 | @ CCF | |||
| Norwich | 7 | at | St Lawrence | 37 | @ LL | |||
| 9/18/2021 | Norwich | 28 | at | Castleton State | 12 | @ ECFC | ||
| Endicott | 29 | at | Catholic | 32 | CCF | |||
| Nichols | 6 | at | Coast Guard | 33 | CCF | |||
| Merchant Marine | 56 | at | SUNY-Maritime | 7 | @ ECFC | |||
| Springfield | 23 | at | Union NY | 30 | @ LL | |||
| Rensselaer | 24 | at | Worcester Polytechnic | 10 | LL | |||
| 9/25/2021 | Christopher Newport | 31 | at | Catholic | 14 | NJAC | ||
| Anna Maria | 29 | at | Coast Guard | 24 | ECFC | |||
| MIT | 27 | at | Dean | 0 | @ ECFC | |||
| Springfield | 21 | at | Husson | 26 | @ CCF | |||
| Kean | 7 | at | Merchant Marine | 56 | NJAC | |||
| Worcester Polytechnic | 10 | at | Montclair State | 31 | @ NJAC | |||
| Endicott | 30 | at | Norwich | 21 | CCF | |||
| 10/2/2021 | MIT | 13 | at | Catholic | 23 | |||
| Norwich | 24 | at | Coast Guard | 21 | ||||
| Worcester Polytechnic | 28 | at | Merchant Marine | 31 | ||||
| 10/9/2021 | Merchant Marine | 49 | at | Norwich | 14 | |||
| Coast Guard | 0 | at | Springfield | 60 | ||||
| Catholic | 30 | at | Worcester Polytechnic | 7 | ||||
| 10/16/2021 | Coast Guard | 7 | at | Catholic | 30 | |||
| MIT | 34 | at | Merchant Marine | 56 | ||||
| Springfield | 56 | at | Norwich | 7 | ||||
| 10/23/2021 | Catholic | 34 | at | Merchant Marine | 44 | |||
| Norwich | 37 | at | MIT | 48 | ||||
| Springfield | 46 | at | Worcester Polytechnic | 17 | ||||
| 10/30/2021 | MIT | 21 | at | Coast Guard | 7 | |||
| Worcester Polytechnic | 28 | at | Norwich | 2 | ||||
| Merchant Marine | 23 | at | Springfield | 28 | ||||
| 11/6/2021 | Norwich | 14 | at | Catholic | 35 | |||
| Springfield | 17 | at | MIT | 7 | ||||
| Coast Guard | 6 | at | Worcester Polytechnic | 38 | ||||
| 11/13/2021 | Merchant Marine | 49 | at | Coast Guard | 14 | |||
| Worcester Polytechnic | 10 | at | MIT | 38 | ||||
| Catholic | 14 | at | Springfield | 28 | ||||
| 11/20/2021 | Springfield | 21 | at | Cortland | 26 | @ E8 | ||
| Merchant Marine | 63 | at | Western New England | 35 | @ CCF |