| 9/4/2021 | Fitchburg State (0-10) | 6 | at | Dean | 42 | MSCAC | ||
| 9/11/2021 | Dean | 29 | at | UMass Dartmouth (9-2) | 48 | at MSCAC | ||
| 9/17/2021 | Dean | 14 | at | Husson (7-3) | 42 | at CCF | ||
| 9/25/2021 | MIT (5-4) | 27 | at | Dean | 0 | NEWMAC | ||
| 10/2/2021 | Dean | 35 | at | Gallaudet (4-3,3-3) | 42 | |||
| 10/9/2021 | Castleton State (6-4,4-2) | 21 | at | Dean | 13 | |||
| 10/16/2021 | Dean | 39 | at | Keystone (0-10,0-6) | 36 | |||
| 10/23/2021 | Dean | 32 | at | Anna Maria (7-3,5-1) | 45 | |||
| 10/30/2021 | SUNY-Maritime (3-6,3-3) | 31 | at | Dean | 27 | |||
| 11/13/2021 | Alfred State (6-5,5-1) | 37 | at | Dean | 15 |
| vs Dean | vs Other Opponents | Dean compared to OOs | |
| Record: | 8-2 | 39-48 | |
| Points Scored: | 33.50 | 21.90 | -11.60 |
| Points Allowed: | 24.60 | 26.33 | -1.73 |
| Margin: | 8.90 | -4.43 | -13.33 |
| Total Points: | 58.10 | 48.23 | 9.87 |