| 9/4/2021 | Plymouth State (5-5) | 0 | at | Castleton State | 13 | MSCAC | ||
| 9/11/2021 | Castleton State | 35 | at | Fitchburg State (0-10) | 0 | at MSCAC | ||
| 9/18/2021 | Norwich (2-8) | 28 | at | Castleton State | 12 | NEWMAC | ||
| 9/25/2021 | Castleton State | 3 | at | St Lawrence (5-5) | 55 | at LL | ||
| 10/2/2021 | Castleton State | 16 | at | SUNY-Maritime (3-6,3-3) | 19 | |||
| 10/9/2021 | Castleton State | 21 | at | Dean (2-8,1-5) | 13 | |||
| 10/23/2021 | Keystone (0-10,0-6) | 0 | at | Castleton State | 41 | |||
| 10/30/2021 | Anna Maria (7-3,5-1) | 31 | at | Castleton State | 38 | |||
| 11/6/2021 | Castleton State | 24 | at | Alfred State (6-5,5-1) | 35 | |||
| 11/13/2021 | Gallaudet (4-3,3-3) | 30 | at | Castleton State | 31 |
| vs Castleton State | vs Other Opponents | Castleton State compared to OOs | |
| Record: | 4-6 | 30-57 | |
| Points Scored: | 21.10 | 20.76 | -0.34 |
| Points Allowed: | 23.40 | 29.25 | -5.85 |
| Margin: | -2.30 | -8.49 | -6.19 |
| Total Points: | 44.50 | 50.01 | -5.51 |