| 9/3/2021 | Worcester State | 20 | at | Worcester Polytechnic (3-7) | 38 | at NEWMAC | ||
| 9/11/2021 | Union NY (8-2) | 62 | at | Worcester State | 13 | LL | ||
| 9/18/2021 | Fitchburg State (0-10,0-8) | 35 | at | Worcester State | 38 | |||
| 9/25/2021 | Worcester State | 7 | at | UMass Dartmouth (9-2,6-2) | 52 | |||
| 10/9/2021 | Bridgewater State MA (6-4,6-2) | 49 | at | Worcester State | 13 | |||
| 10/16/2021 | Worcester State | 28 | at | Massachusetts Maritime (4-6,3-5) | 24 | |||
| 10/23/2021 | Worcester State | 14 | at | Plymouth State (5-5,5-3) | 42 | |||
| 10/30/2021 | Western Connecticut (5-5,4-4) | 56 | at | Worcester State | 30 | |||
| 11/6/2021 | Worcester State | 33 | at | Westfield State (1-9,1-7) | 30 | |||
| 11/13/2021 | Framingham State (8-3,8-0) | 40 | at | Worcester State | 21 |
| vs Worcester State | vs Other Opponents | Worcester State compared to OOs | |
| Record: | 7-3 | 42-50 | |
| Points Scored: | 42.80 | 20.54 | -22.26 |
| Points Allowed: | 21.70 | 22.65 | -0.95 |
| Margin: | 21.10 | -2.11 | -23.21 |
| Total Points: | 64.50 | 43.19 | 21.31 |