| 9/4/2021 | St Lawrence (5-5) | 14 | at | Endicott | 27 | LL | ||
| 9/10/2021 | Worcester Polytechnic (3-7) | 21 | at | Endicott | 28 | NEWMAC | ||
| 9/18/2021 | Endicott | 29 | at | Catholic (6-4) | 32 | at NEWMAC | ||
| 9/25/2021 | Endicott | 30 | at | Norwich (2-8) | 21 | at NEWMAC | ||
| 10/2/2021 | Curry (3-6,1-5) | 27 | at | Endicott | 34 | |||
| 10/9/2021 | Western New England (7-4,5-1) | 21 | at | Endicott | 45 | |||
| 10/16/2021 | Endicott | 24 | at | Husson (7-3,4-2) | 17 | |||
| 10/23/2021 | Endicott | 14 | at | Salve Regina (8-2,4-2) | 21 | |||
| 10/30/2021 | University of New England (4-5,2-4) | 17 | at | Endicott | 19 | |||
| 11/13/2021 | Endicott | 37 | at | Nichols (2-8,0-6) | 3 | |||
| 11/20/2021 | Rensselaer (11-2) | 20 | at | Endicott | 14 | LL |
| vs Endicott | vs Other Opponents | Endicott compared to OOs | |
| Record: | 3-8 | 55-46 | |
| Points Scored: | 19.45 | 22.46 | 3.01 |
| Points Allowed: | 27.36 | 23.06 | 4.30 |
| Margin: | -7.91 | -0.60 | 7.31 |
| Total Points: | 46.81 | 45.52 | 1.29 |