| 9/4/2021 | Randolph-Macon | 31 | at | Dickinson (4-6) | 21 | at Cen | ||
| 9/11/2021 | Catholic (6-4) | 10 | at | Randolph-Macon | 62 | NEWMAC | ||
| 9/18/2021 | Randolph-Macon | 31 | at | Bridgewater VA (4-6,2-5) | 13 | |||
| 9/25/2021 | Washington and Lee (8-3,5-1) | 25 | at | Randolph-Macon | 24 | |||
| 10/2/2021 | Randolph-Macon | 44 | at | Ferrum (6-4,4-3) | 21 | |||
| 10/9/2021 | Emory & Henry (6-4) | 31 | at | Randolph-Macon | 34 | D2Ind (D2) | ||
| 10/16/2021 | Randolph-Macon | 58 | at | Guilford (1-7,0-6) | 0 | |||
| 10/23/2021 | Apprentice (1-7) | 7 | at | Randolph-Macon | 49 | None (Unk?) | ||
| 10/30/2021 | Shenandoah (7-3,3-3) | 14 | at | Randolph-Macon | 45 | |||
| 11/13/2021 | Hampden-Sydney (5-5,4-2) | 14 | at | Randolph-Macon | 37 |
| vs Randolph-Macon | vs Other Opponents | Randolph-Macon compared to OOs | |
| Record: | 1-9 | 47-40 | |
| Points Scored: | 15.60 | 26.33 | 10.73 |
| Points Allowed: | 41.50 | 24.46 | 17.04 |
| Margin: | -25.90 | 1.87 | 27.77 |
| Total Points: | 57.10 | 50.79 | 6.31 |