| 9/3/2016 | South Alabama (6-7) | 21 | at | Mississippi State | 20 | SBC | ||
| 9/10/2016 | South Carolina (6-7,3-5) | 14 | at | Mississippi State | 27 | |||
| 9/17/2016 | Mississippi State | 20 | at | LSU (8-4,5-3) | 23 | |||
| 9/24/2016 | Mississippi State | 47 | vs | Massachusetts (2-10) | 35 | Foxboro MA | vs MAC | |
| 10/8/2016 | Auburn (8-5,5-3) | 38 | at | Mississippi State | 14 | |||
| 10/14/2016 | Mississippi State | 21 | at | BYU (9-4) | 28 | at Ind | ||
| 10/22/2016 | Mississippi State | 38 | at | Kentucky (7-6,4-4) | 40 | |||
| 10/29/2016 | Samford (7-5) | 41 | at | Mississippi State | 56 | SoCon (1AA) | ||
| 11/5/2016 | Texas A&M (8-5,4-4) | 28 | at | Mississippi State | 35 | |||
| 11/12/2016 | Mississippi State | 3 | at | Alabama (14-1,9-0) | 51 | |||
| 11/19/2016 | Arkansas (7-6,3-5) | 58 | at | Mississippi State | 42 | |||
| 11/26/2016 | Mississippi State | 55 | at | Mississippi (5-7,2-6) | 20 | |||
| 12/26/2016 | Miami-Ohio (6-7) | 16 | vs | Mississippi State | 17 | St. Petersburg Bowl | MAC |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 7-6 | 86-68 | |
| Points Scored: | 31.77 | 29.38 | -2.39 |
| Points Allowed: | 30.38 | 24.42 | 5.96 |
| Margin: | 1.39 | 4.96 | 3.57 |
| Total Points: | 62.15 | 53.80 | 8.35 |