| 9/2/2010 | Northern Illinois | 10 | @ | Iowa State | 27 | ||||
| 9/11/2010 | North Dakota 1AA | 17 | @ | Northern Illinois | 23 | ||||
| 9/18/2010 | Northern Illinois | 22 | @ | Illinois | 28 | ||||
| 9/25/2010 | Northern Illinois | 34 | @ | Minnesota | 23 | ||||
| 10/2/2010 | Northern Illinois | 50 | @ | Akron | 14 | MAC | |||
| 10/9/2010 | Temple | 17 | @ | Northern Illinois | 31 | MAC | |||
| 10/16/2010 | Buffalo | 14 | @ | Northern Illinois | 45 | MAC | |||
| 10/23/2010 | Central Michigan | 7 | @ | Northern Illinois | 33 | MAC | |||
| 10/30/2010 | Northern Illinois | 28 | @ | Western Michigan | 21 | MAC | |||
| 11/9/2010 | Toledo | 30 | @ | Northern Illinois | 65 | MAC | |||
| 11/20/2010 | Northern Illinois | 59 | @ | Ball State | 21 | MAC | |||
| 11/26/2010 | Northern Illinois | 71 | @ | Eastern Michigan | 3 | MAC | |||
| 12/3/2010 | Northern Illinois | 21 | vs | Miami-Ohio | 26 | MAC | MAC Championship | ||
| 12/18/2010 | Northern Illinois | 40 | vs | Fresno State | 17 | Boise - Humanitarian Bowl |