| 9/4/2010 | Syracuse | 29 | @ | Akron | 3 | ||||
| 9/11/2010 | Gardner-Webb 1AA | 38 | @ | Akron | 37 | OT | |||
| 9/18/2010 | Akron | 10 | @ | Kentucky | 47 | ||||
| 9/25/2010 | Akron | 20 | @ | Indiana | 35 | ||||
| 10/2/2010 | Northern Illinois | 50 | @ | Akron | 14 | MAC | |||
| 10/9/2010 | Akron | 17 | @ | Kent State | 28 | MAC | |||
| 10/16/2010 | Akron | 10 | @ | Ohio | 38 | MAC | |||
| 10/23/2010 | Western Michigan | 56 | @ | Akron | 10 | MAC | |||
| 10/30/2010 | Akron | 0 | @ | Temple | 30 | MAC | |||
| 11/6/2010 | Akron | 30 | @ | Ball State | 37 | 2 OT | MAC | ||
| 11/17/2010 | Miami-Ohio | 19 | @ | Akron | 14 | MAC | |||
| 11/26/2010 | Buffalo | 14 | @ | Akron | 22 | MAC |