| 9/4/2010 | Miami-Ohio | 12 | @ | Florida | 34 | ||||
| 9/11/2010 | Eastern Michigan | 21 | @ | Miami-Ohio | 28 | MAC | |||
| 9/18/2010 | Colorado State | 10 | @ | Miami-Ohio | 31 | ||||
| 9/25/2010 | Miami-Ohio | 13 | @ | Missouri | 51 | ||||
| 10/2/2010 | Kent State | 21 | @ | Miami-Ohio | 27 | MAC | |||
| 10/9/2010 | Miami-Ohio | 3 | @ | Cincinnati | 45 | ||||
| 10/16/2010 | Miami-Ohio | 27 | @ | Central Michigan | 20 | MAC | |||
| 10/23/2010 | Ohio | 34 | @ | Miami-Ohio | 13 | MAC | |||
| 10/30/2010 | Miami-Ohio | 21 | @ | Buffalo | 9 | MAC | |||
| 11/10/2010 | Miami-Ohio | 24 | @ | Bowling Green | 21 | MAC | |||
| 11/17/2010 | Miami-Ohio | 19 | @ | Akron | 14 | MAC | |||
| 11/23/2010 | Temple | 3 | @ | Miami-Ohio | 23 | MAC | |||
| 12/3/2010 | Northern Illinois | 21 | vs | Miami-Ohio | 26 | MAC | MAC Championship | ||
| 1/6/2011 | Middle Tenn State | 21 | vs | Miami-Ohio | 35 | Mobile - GoDaddy.com Bowl |