| 9/3/2010 | Arizona | 41 | @ | Toledo | 2 | ||||
| 9/11/2010 | Toledo | 20 | @ | Ohio | 13 | MAC | |||
| 9/18/2010 | Toledo | 37 | @ | Western Michigan | 24 | MAC | |||
| 9/25/2010 | Toledo | 31 | @ | Purdue | 20 | ||||
| 10/2/2010 | Wyoming | 20 | @ | Toledo | 15 | ||||
| 10/9/2010 | Toledo | 14 | @ | Boise State | 57 | ||||
| 10/16/2010 | Kent State | 21 | @ | Toledo | 34 | MAC | |||
| 10/23/2010 | Ball State | 24 | @ | Toledo | 31 | MAC | |||
| 10/30/2010 | Toledo | 42 | @ | Eastern Michigan | 7 | MAC | |||
| 11/9/2010 | Toledo | 30 | @ | Northern Illinois | 65 | MAC | |||
| 11/17/2010 | Bowling Green | 14 | @ | Toledo | 33 | MAC | |||
| 11/26/2010 | Central Michigan | 31 | @ | Toledo | 42 | MAC | |||
| 12/26/2010 | Florida Intl | 34 | vs | Toledo | 32 | Detroit - Little Ceasar's Bowl |