| 9/2/2010 | Northern Illinois | 10 | @ | Iowa State | 27 | ||||
| 9/11/2010 | Iowa State | 7 | @ | Iowa | 35 | ||||
| 9/18/2010 | Iowa State | 20 | vs | Kansas State | 27 | B12 | Kansas City MO | ||
| 9/25/2010 | Northern Iowa 1AA | 0 | @ | Iowa State | 27 | ||||
| 10/2/2010 | Texas Tech | 38 | @ | Iowa State | 52 | B12 | |||
| 10/9/2010 | Utah | 68 | @ | Iowa State | 27 | ||||
| 10/16/2010 | Iowa State | 0 | @ | Oklahoma | 52 | B12 | |||
| 10/23/2010 | Iowa State | 28 | @ | Texas | 21 | B12 | |||
| 10/30/2010 | Kansas | 16 | @ | Iowa State | 28 | B12 | |||
| 11/6/2010 | Nebraska | 31 | @ | Iowa State | 30 | OT | B12 | ||
| 11/13/2010 | Iowa State | 14 | @ | Colorado | 34 | B12 | |||
| 11/20/2010 | Missouri | 14 | @ | Iowa State | 0 | B12 |