| 9/4/2010 | Illinois | 13 | vs | Missouri | 23 | St Louis MO | |||
| 9/11/2010 | Southern Illinois 1AA | 3 | @ | Illinois | 35 | ||||
| 9/18/2010 | Northern Illinois | 22 | @ | Illinois | 28 | ||||
| 10/2/2010 | Ohio State | 24 | @ | Illinois | 13 | B10 | |||
| 10/9/2010 | Illinois | 33 | @ | Penn State | 13 | B10 | |||
| 10/16/2010 | Illinois | 6 | @ | Michigan State | 26 | B10 | |||
| 10/23/2010 | Indiana | 13 | @ | Illinois | 43 | B10 | |||
| 10/30/2010 | Purdue | 10 | @ | Illinois | 44 | B10 | |||
| 11/6/2010 | Illinois | 65 | @ | Michigan | 67 | 3 OT | B10 | ||
| 11/13/2010 | Minnesota | 38 | @ | Illinois | 34 | B10 | |||
| 11/20/2010 | Illinois | 48 | @ | Northwestern | 27 | B10 | |||
| 12/3/2010 | Illinois | 23 | @ | Fresno State | 25 | ||||
| 12/29/2010 | Illinois | 38 | vs | Baylor | 14 | Houston - Texas Bowl |