| 9/2/2010 | Rhode Island 1AA | 0 | @ | Buffalo | 31 | ||||
| 9/11/2010 | Buffalo | 6 | @ | Baylor | 34 | ||||
| 9/18/2010 | UCF | 24 | @ | Buffalo | 10 | ||||
| 9/25/2010 | Buffalo | 21 | @ | Connecticut | 45 | ||||
| 10/2/2010 | Buffalo | 28 | @ | Bowling Green | 26 | MAC | |||
| 10/16/2010 | Buffalo | 14 | @ | Northern Illinois | 45 | MAC | |||
| 10/23/2010 | Temple | 42 | @ | Buffalo | 0 | MAC | |||
| 10/30/2010 | Miami-Ohio | 21 | @ | Buffalo | 9 | MAC | |||
| 11/4/2010 | Buffalo | 17 | @ | Ohio | 34 | MAC | |||
| 11/12/2010 | Ball State | 20 | @ | Buffalo | 3 | MAC | |||
| 11/20/2010 | Eastern Michigan | 21 | @ | Buffalo | 17 | MAC | |||
| 11/26/2010 | Buffalo | 14 | @ | Akron | 22 | MAC |