| 9/4/2010 | Army | 31 | @ | Eastern Michigan | 27 | ||||
| 9/11/2010 | Eastern Michigan | 21 | @ | Miami-Ohio | 28 | MAC | |||
| 9/18/2010 | Central Michigan | 52 | @ | Eastern Michigan | 14 | MAC | |||
| 9/25/2010 | Eastern Michigan | 20 | @ | Ohio State | 73 | ||||
| 10/2/2010 | Ohio | 30 | @ | Eastern Michigan | 17 | MAC | |||
| 10/9/2010 | Eastern Michigan | 6 | @ | Vanderbilt | 52 | ||||
| 10/16/2010 | Eastern Michigan | 41 | @ | Ball State | 38 | OT | MAC | ||
| 10/23/2010 | Eastern Michigan | 21 | @ | Virginia | 48 | ||||
| 10/30/2010 | Toledo | 42 | @ | Eastern Michigan | 7 | MAC | |||
| 11/13/2010 | Eastern Michigan | 30 | @ | Western Michigan | 45 | MAC | |||
| 11/20/2010 | Eastern Michigan | 21 | @ | Buffalo | 17 | MAC | |||
| 11/26/2010 | Northern Illinois | 71 | @ | Eastern Michigan | 3 | MAC |