| 9/4/2010 | Western Michigan | 14 | @ | Michigan State | 38 | ||||
| 9/11/2010 | Nicholls State 1AA | 14 | @ | Western Michigan | 49 | ||||
| 9/18/2010 | Toledo | 37 | @ | Western Michigan | 24 | MAC | |||
| 10/2/2010 | Idaho | 33 | @ | Western Michigan | 13 | ||||
| 10/9/2010 | Western Michigan | 45 | @ | Ball State | 16 | MAC | |||
| 10/16/2010 | Western Michigan | 20 | @ | Notre Dame | 44 | ||||
| 10/23/2010 | Western Michigan | 56 | @ | Akron | 10 | MAC | |||
| 10/30/2010 | Northern Illinois | 28 | @ | Western Michigan | 21 | MAC | |||
| 11/5/2010 | Western Michigan | 22 | @ | Central Michigan | 26 | MAC | |||
| 11/13/2010 | Eastern Michigan | 30 | @ | Western Michigan | 45 | MAC | |||
| 11/20/2010 | Kent State | 3 | @ | Western Michigan | 38 | MAC | |||
| 11/26/2010 | Western Michigan | 41 | @ | Bowling Green | 7 | MAC |