| 9/4/2010 | Illinois | 13 | vs | Missouri | 23 | St Louis MO | |||
| 9/11/2010 | McNeese State 1AA | 6 | @ | Missouri | 50 | ||||
| 9/18/2010 | San Diego State | 24 | @ | Missouri | 27 | ||||
| 9/25/2010 | Miami-Ohio | 13 | @ | Missouri | 51 | ||||
| 10/9/2010 | Colorado | 0 | @ | Missouri | 26 | B12 | |||
| 10/16/2010 | Missouri | 30 | @ | Texas A&M | 9 | B12 | |||
| 10/23/2010 | Oklahoma | 27 | @ | Missouri | 36 | B12 | |||
| 10/30/2010 | Missouri | 17 | @ | Nebraska | 31 | B12 | |||
| 11/6/2010 | Missouri | 17 | @ | Texas Tech | 24 | B12 | |||
| 11/13/2010 | Kansas State | 28 | @ | Missouri | 38 | B12 | |||
| 11/20/2010 | Missouri | 14 | @ | Iowa State | 0 | B12 | |||
| 11/27/2010 | Missouri | 35 | vs | Kansas | 7 | B12 | Kansas City MO | ||
| 12/28/2010 | Missouri | 24 | vs | Iowa | 27 | Phoenix - Insight Bowl |