| 9/4/2010 | Colorado State | 3 | vs | Colorado | 24 | Denver CO | |||
| 9/11/2010 | Colorado | 7 | @ | California | 52 | ||||
| 9/18/2010 | Hawaii | 13 | @ | Colorado | 31 | ||||
| 10/2/2010 | Georgia | 27 | @ | Colorado | 29 | ||||
| 10/9/2010 | Colorado | 0 | @ | Missouri | 26 | B12 | |||
| 10/16/2010 | Baylor | 31 | @ | Colorado | 25 | B12 | |||
| 10/23/2010 | Texas Tech | 27 | @ | Colorado | 24 | B12 | |||
| 10/30/2010 | Colorado | 10 | @ | Oklahoma | 43 | B12 | |||
| 11/6/2010 | Colorado | 45 | @ | Kansas | 52 | B12 | |||
| 11/13/2010 | Iowa State | 14 | @ | Colorado | 34 | B12 | |||
| 11/20/2010 | Kansas State | 36 | @ | Colorado | 44 | B12 | |||
| 11/26/2010 | Colorado | 17 | @ | Nebraska | 45 | B12 |