| 9/4/2010 | Western Kentucky | 10 | @ | Nebraska | 49 | ||||
| 9/11/2010 | Idaho | 17 | @ | Nebraska | 38 | ||||
| 9/18/2010 | Nebraska | 56 | @ | Washington | 21 | ||||
| 9/25/2010 | South Dakota State 1AA | 3 | @ | Nebraska | 17 | ||||
| 10/7/2010 | Nebraska | 48 | @ | Kansas State | 13 | B12 | |||
| 10/16/2010 | Texas | 20 | @ | Nebraska | 13 | B12 | |||
| 10/23/2010 | Nebraska | 51 | @ | Oklahoma State | 41 | B12 | |||
| 10/30/2010 | Missouri | 17 | @ | Nebraska | 31 | B12 | |||
| 11/6/2010 | Nebraska | 31 | @ | Iowa State | 30 | OT | B12 | ||
| 11/13/2010 | Kansas | 3 | @ | Nebraska | 20 | B12 | |||
| 11/20/2010 | Nebraska | 6 | @ | Texas A&M | 9 | B12 | |||
| 11/26/2010 | Colorado | 17 | @ | Nebraska | 45 | B12 | |||
| 12/4/2010 | Nebraska | 20 | vs | Oklahoma | 23 | B12 | Arlington TX-Big 12 Championship | ||
| 12/30/2010 | Nebraska | 7 | vs | Washington | 19 | San Diego - Holiday Bowl |