| 9/4/2010 | UCLA | 22 | @ | Kansas State | 31 | ||||
| 9/11/2010 | Missouri State 1AA | 24 | @ | Kansas State | 48 | ||||
| 9/18/2010 | Iowa State | 20 | vs | Kansas State | 27 | B12 | Kansas City MO | ||
| 9/25/2010 | UCF | 13 | @ | Kansas State | 17 | ||||
| 10/7/2010 | Nebraska | 48 | @ | Kansas State | 13 | B12 | |||
| 10/14/2010 | Kansas State | 59 | @ | Kansas | 7 | B12 | |||
| 10/23/2010 | Kansas State | 42 | @ | Baylor | 47 | B12 | |||
| 10/30/2010 | Oklahoma State | 24 | @ | Kansas State | 14 | B12 | |||
| 11/6/2010 | Texas | 14 | @ | Kansas State | 39 | B12 | |||
| 11/13/2010 | Kansas State | 28 | @ | Missouri | 38 | B12 | |||
| 11/20/2010 | Kansas State | 36 | @ | Colorado | 44 | B12 | |||
| 11/27/2010 | Kansas State | 49 | @ | North Texas | 41 | ||||
| 12/30/2010 | Kansas State | 34 | vs | Syracuse | 36 | New York - Pinstripe Bowl |