| 9/4/2010 | Stephen F. Austin 1AA | 7 | @ | Texas A&M | 48 | ||||
| 9/11/2010 | Louisiana Tech | 16 | @ | Texas A&M | 48 | ||||
| 9/18/2010 | Florida Intl | 20 | @ | Texas A&M | 27 | ||||
| 9/30/2010 | Texas A&M | 35 | @ | Oklahoma State | 38 | B12 | |||
| 10/9/2010 | Arkansas | 24 | vs | Texas A&M | 17 | Arlington TX | |||
| 10/16/2010 | Missouri | 30 | @ | Texas A&M | 9 | B12 | |||
| 10/23/2010 | Texas A&M | 45 | @ | Kansas | 10 | B12 | |||
| 10/30/2010 | Texas Tech | 27 | @ | Texas A&M | 45 | B12 | |||
| 11/6/2010 | Oklahoma | 19 | @ | Texas A&M | 33 | B12 | |||
| 11/13/2010 | Texas A&M | 42 | @ | Baylor | 30 | B12 | |||
| 11/20/2010 | Nebraska | 6 | @ | Texas A&M | 9 | B12 | |||
| 11/25/2010 | Texas A&M | 24 | @ | Texas | 17 | B12 | |||
| 1/7/2011 | LSU | 41 | vs | Texas A&M | 24 | Dallas - Cotton Bowl |