| 9/4/2010 | North Dakota State 1AA | 6 | @ | Kansas | 3 | ||||
| 9/11/2010 | Georgia Tech | 25 | @ | Kansas | 28 | ||||
| 9/17/2010 | Kansas | 16 | @ | Southern Miss | 31 | ||||
| 9/25/2010 | New Mexico State | 16 | @ | Kansas | 42 | ||||
| 10/2/2010 | Kansas | 7 | @ | Baylor | 55 | B12 | |||
| 10/14/2010 | Kansas State | 59 | @ | Kansas | 7 | B12 | |||
| 10/23/2010 | Texas A&M | 45 | @ | Kansas | 10 | B12 | |||
| 10/30/2010 | Kansas | 16 | @ | Iowa State | 28 | B12 | |||
| 11/6/2010 | Colorado | 45 | @ | Kansas | 52 | B12 | |||
| 11/13/2010 | Kansas | 3 | @ | Nebraska | 20 | B12 | |||
| 11/20/2010 | Oklahoma State | 48 | @ | Kansas | 14 | B12 | |||
| 11/27/2010 | Missouri | 35 | vs | Kansas | 7 | B12 | Kansas City MO |