| 9/4/2010 | Eastern Illinois 1AA | 7 | @ | Iowa | 37 | ||||
| 9/11/2010 | Iowa State | 7 | @ | Iowa | 35 | ||||
| 9/18/2010 | Iowa | 27 | @ | Arizona | 34 | ||||
| 9/25/2010 | Ball State | 0 | @ | Iowa | 45 | ||||
| 10/2/2010 | Penn State | 3 | @ | Iowa | 24 | B10 | |||
| 10/16/2010 | Iowa | 38 | @ | Michigan | 28 | B10 | |||
| 10/23/2010 | Wisconsin | 31 | @ | Iowa | 30 | B10 | |||
| 10/30/2010 | Michigan State | 6 | @ | Iowa | 37 | B10 | |||
| 11/6/2010 | Iowa | 18 | @ | Indiana | 13 | B10 | |||
| 11/13/2010 | Iowa | 17 | @ | Northwestern | 21 | B10 | |||
| 11/20/2010 | Ohio State | 20 | @ | Iowa | 17 | B10 | |||
| 11/27/2010 | Iowa | 24 | @ | Minnesota | 27 | B10 | |||
| 12/28/2010 | Missouri | 24 | vs | Iowa | 27 | Phoenix - Insight Bowl |