| 4-8 | — | 0 | (2 Common Ops) | 0 | Akron | 1-11 |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 9/4/2010 | L 3-29 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 11/17/2010 | L 14-19 |
| 1-1 | 15-8 | 0-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Arkansas State | 4-8 |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 10/2/2010 | L 24-34 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Army | 7-6 |
| W 69-38 | 11/20/2010 | Rutgers (3-7) | 10/16/2010 | L 20-23 1 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Baylor | 7-6 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 11/20/2010 | L 24-53 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Boise State | 12-1 |
| L 14-28 at | 9/4/2010 | Fresno State (7-4) | 11/19/2010 | W 51-0 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Boston College | 7-6 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 10/9/2010 | L 17-44 at |
| L 7-31 | 10/30/2010 | Syracuse (7-4) | 11/27/2010 | W 16-7 at |
| 0-2 | 14-8 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Bowling Green | 2-10 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 11/10/2010 | L 21-24 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Buffalo | 2-10 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 9/25/2010 | L 21-45 at |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 10/30/2010 | L 9-21 |
| 1-1 | 15-8 | 0-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Cal Poly | 0-1 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 10/2/2010 | L 17-38 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Central Michigan | 3-9 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 10/16/2010 | L 20-27 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Clemson | 6-7 |
| L 19-30 at | 9/16/2010 | North Carolina State (8-3) | 11/6/2010 | W 14-13 |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 12/31/2010 | L 26-31 vs |
| 0-2 | 14-8 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Coastal Carolina | 0-1 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 9/4/2010 | L 0-31 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Colgate | 0-1 |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 9/25/2010 | L 7-42 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Colorado | 5-7 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 10/30/2010 | L 10-43 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Colorado State | 3-9 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 9/18/2010 | L 10-31 at |
|
| 4-7 | — | 0 | (7 Common Ops) | 1 | Connecticut | 7-5 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 1/1/2011 | L 20-48 vs |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 10/23/2010 | L 0-26 at |
| L 30-38 | 10/22/2010 | South Florida (7-4) | 12/4/2010 | W 19-16 at |
| L 7-31 | 10/30/2010 | Syracuse (7-4) | 11/20/2010 | W 23-6 at |
| L 10-37 at | 11/13/2010 | West Virginia (8-3) | 10/29/2010 | W 16-13 1 |
| W 69-38 | 11/20/2010 | Rutgers (3-7) | 10/8/2010 | L 24-27 at |
| L 10-28 | 12/4/2010 | Pittsburgh (7-4) | 11/11/2010 | W 30-28 |
| 2-5 | 48-29 | 4-3 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | East Carolina | 6-7 |
| L 19-30 at | 9/16/2010 | North Carolina State (8-3) | 10/16/2010 | W 33-27 1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Eastern Kentucky | 0-1 |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 9/11/2010 | L 13-23 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Eastern Michigan | 2-10 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 9/11/2010 | L 21-28 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Florida | 8-5 |
| W 45-3 | 10/9/2010 | Miami-Ohio (10-2) | 9/4/2010 | W 34-12 |
| L 30-38 | 10/22/2010 | South Florida (7-4) | 9/11/2010 | W 38-14 |
| 1-1 | 17-6 | 2-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Florida Atlantic | 4-8 |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 10/2/2010 | L 3-21 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Florida Intl | 7-6 |
| W 69-38 | 11/20/2010 | Rutgers (3-7) | 9/11/2010 | L 14-19 |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 10/2/2010 | L 17-44 at |
| 1-1 | 9-12 | 0-2 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Florida State | 10-4 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 9/11/2010 | L 17-47 at |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 10/28/2010 | L 24-28 at |
| 0-2 | 17-6 | 0-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Georgia Tech | 6-7 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 9/25/2010 | L 28-45 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Hawaii | 10-4 |
| L 14-28 at | 9/4/2010 | Fresno State (7-4) | 10/9/2010 | W 49-27 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Idaho | 6-7 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 11/27/2010 | L 20-23 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 12/3/2010 | L 23-25 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Iowa State | 5-7 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 10/16/2010 | L 0-52 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kansas State | 7-6 |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 12/30/2010 | L 34-36 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 10/2/2010 | L 21-27 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Kentucky | 6-7 |
| W 35-27 at | 10/15/2010 | Louisville (7-4) | 9/4/2010 | W 23-16 at |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 1/8/2011 | L 10-27 vs |
| 1-1 | 13-9 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Louisiana Tech | 5-7 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 11/6/2010 | L 34-40 |
|
| 3-8 | — | 1 | (6 Common Ops) | 0 | Louisville | 7-5 |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 11/13/2010 | L 21-24 1 |
| L 7-31 | 10/30/2010 | Syracuse (7-4) | 11/6/2010 | W 28-20 at |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 11/20/2010 | L 10-17 |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 11/26/2010 | W 40-13 at |
| L 17-38 at | 11/27/2010 | Connecticut (7-4) | 10/23/2010 | W 26-0 |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 10/30/2010 | L 3-21 at |
| 1-5 | 37-28 | 3-3 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | LSU | 11-2 |
| L 10-37 at | 11/13/2010 | West Virginia (8-3) | 9/25/2010 | W 20-14 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Maine | 0-1 |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 9/18/2010 | L 14-38 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Marshall | 5-7 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 9/10/2010 | L 21-24 1 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Maryland | 9-4 |
| L 19-30 at | 9/16/2010 | North Carolina State (8-3) | 11/27/2010 | W 38-31 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 9/18/2010 | L 17-31 at |
| 0-2 | 15-7 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Memphis | 1-11 |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 10/9/2010 | L 0-56 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Miami-Florida | 7-6 |
| L 10-28 | 12/4/2010 | Pittsburgh (7-4) | 9/23/2010 | W 31-3 at |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 11/27/2010 | L 20-23 1 |
| 0-2 | 13-9 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 17-38 at | 11/27/2010 | Connecticut (7-4) | 9/4/2010 | W 30-10 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Middle Tenn State | 6-7 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 1/6/2011 | L 21-35 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Mississippi | 4-8 |
| L 14-28 at | 9/4/2010 | Fresno State (7-4) | 9/25/2010 | W 55-38 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Missouri | 10-3 |
| L 29-31 | 9/25/2010 | Oklahoma (11-1) | 10/23/2010 | W 36-27 |
| W 45-3 | 10/9/2010 | Miami-Ohio (10-2) | 9/25/2010 | W 51-13 |
| 1-1 | 21-3 | 2-0 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Nebraska | 10-4 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 12/4/2010 | L 20-23 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Nevada | 13-1 |
| L 14-28 at | 9/4/2010 | Fresno State (7-4) | 11/13/2010 | W 35-34 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | New Hampshire | 0-1 |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 9/11/2010 | L 16-38 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | New Mexico State | 2-10 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 10/16/2010 | L 10-33 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Norfolk State | 0-1 |
| W 69-38 | 11/20/2010 | Rutgers (3-7) | 9/2/2010 | L 0-31 at |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | North Carolina | 8-5 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 11/20/2010 | L 25-29 |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 9/25/2010 | W 17-13 at |
| 1-1 | 11-10 | 1-1 |
|
| 4-7 | — | 0 | (1 Common Ops) | 1 | North Carolina State | 8-4 |
| L 10-37 at | 11/13/2010 | West Virginia (8-3) | 12/28/2010 | W 23-7 vs |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Northern Illinois | 11-3 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 12/3/2010 | L 21-26 vs |
| L 14-28 at | 9/4/2010 | Fresno State (7-4) | 12/18/2010 | W 40-17 vs |
| 1-1 | 16-7 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 10-28 | 12/4/2010 | Pittsburgh (7-4) | 10/9/2010 | W 23-17 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ohio | 8-5 |
| W 45-3 | 10/9/2010 | Miami-Ohio (10-2) | 10/23/2010 | W 34-13 at |
|
| 4-7 | — | 0 | (1 Common Ops) | 1 | Oklahoma | 11-2 |
| L 17-38 at | 11/27/2010 | Connecticut (7-4) | 1/1/2011 | W 48-20 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oklahoma State | 11-2 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 11/27/2010 | L 41-47 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oregon State | 5-7 |
| W 35-27 at | 10/15/2010 | Louisville (7-4) | 9/18/2010 | W 35-28 |
|
| 4-7 | — | 0 | (6 Common Ops) | 1 | Pittsburgh | 7-5 |
| L 7-31 | 10/30/2010 | Syracuse (7-4) | 10/16/2010 | W 45-14 at |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 10/23/2010 | W 41-21 |
| W 35-27 at | 10/15/2010 | Louisville (7-4) | 10/30/2010 | W 21-3 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 11/11/2010 | L 28-30 at |
| L 30-38 | 10/22/2010 | South Florida (7-4) | 11/20/2010 | W 17-10 at |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 11/26/2010 | L 10-35 |
| 2-4 | 38-27 | 4-2 |
|
| 3-8 | — | 1 | (6 Common Ops) | 0 | Rutgers | 4-7 |
| L 17-38 at | 11/27/2010 | Connecticut (7-4) | 10/8/2010 | W 27-24 |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 10/23/2010 | L 21-41 at |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 11/3/2010 | L 27-28 at |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 11/13/2010 | L 10-13 |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 11/26/2010 | L 13-40 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 12/4/2010 | L 14-35 at |
| 1-5 | 38-28 | 1-5 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | San Jose State | 1-12 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 10/23/2010 | L 18-33 |
|
| 4-7 | — | 0 | (6 Common Ops) | 1 | South Florida | 7-5 |
| W 35-27 at | 10/15/2010 | Louisville (7-4) | 11/13/2010 | W 24-21 1 at |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 10/9/2010 | L 9-13 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 10/14/2010 | L 6-20 at |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 11/3/2010 | W 28-27 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 12/4/2010 | L 16-19 |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 11/20/2010 | L 10-17 |
| 2-4 | 36-29 | 2-4 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Southern Miss | 8-5 |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 12/21/2010 | L 28-31 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Stony Brook | 0-1 |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 9/4/2010 | L 14-59 at |
|
| 4-7 | — | 0 | (6 Common Ops) | 1 | Syracuse | 7-5 |
| L 30-38 | 10/22/2010 | South Florida (7-4) | 10/9/2010 | W 13-9 at |
| L 10-28 | 12/4/2010 | Pittsburgh (6-5) | 10/16/2010 | L 14-45 |
| L 10-37 at | 11/13/2010 | West Virginia (8-3) | 10/23/2010 | W 19-14 at |
| W 35-27 at | 10/15/2010 | Louisville (6-5) | 11/6/2010 | L 20-28 |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 11/13/2010 | W 13-10 at |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 11/20/2010 | L 6-23 |
| 2-4 | 37-28 | 3-3 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Temple | 8-4 |
| L 17-38 at | 11/27/2010 | Connecticut (7-4) | 9/18/2010 | W 30-16 |
| W 45-3 | 10/9/2010 | Miami-Ohio (9-3) | 11/23/2010 | L 3-23 at |
| 1-1 | 16-7 | 1-1 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas | 5-7 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 10/2/2010 | L 20-28 vs |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas A&M | 9-4 |
| L 29-31 | 9/25/2010 | Oklahoma (11-1) | 11/6/2010 | W 33-19 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas Southern | 0-1 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 9/11/2010 | L 3-62 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas Tech | 8-5 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 11/13/2010 | L 7-45 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Tulane | 4-8 |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 10/2/2010 | W 17-14 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | UCF | 11-3 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 9/11/2010 | L 21-28 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | UNLV | 2-11 |
| L 10-37 at | 11/13/2010 | West Virginia (7-4) | 10/9/2010 | L 10-49 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Utah | 10-3 |
| L 10-28 | 12/4/2010 | Pittsburgh (7-4) | 9/2/2010 | W 27-24 1 |
|
| 4-8 | — | 0 | (2 Common Ops) | 0 | Utah State | 4-8 |
| L 14-28 at | 9/4/2010 | Fresno State (6-5) | 9/18/2010 | L 24-41 |
| L 29-31 | 9/25/2010 | Oklahoma (10-2) | 9/4/2010 | L 24-31 at |
| 0-2 | 16-7 | 0-2 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Vanderbilt | 2-10 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 10/2/2010 | L 21-40 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Virginia Tech | 11-3 |
| L 19-30 at | 9/16/2010 | North Carolina State (8-3) | 10/2/2010 | W 41-30 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Wake Forest | 3-9 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 11/13/2010 | L 3-38 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Washington | 7-6 |
| L 7-31 | 10/30/2010 | Syracuse (7-4) | 9/11/2010 | W 41-20 |
|
| 4-7 | — | 0 | (7 Common Ops) | 1 | West Virginia | 8-4 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 12/28/2010 | L 7-23 vs |
| W 35-27 at | 10/15/2010 | Louisville (7-4) | 11/20/2010 | W 17-10 at |
| L 30-38 | 10/22/2010 | South Florida (7-4) | 10/14/2010 | W 20-6 |
| L 7-31 | 10/30/2010 | Syracuse (6-5) | 10/23/2010 | L 14-19 |
| W 69-38 | 11/20/2010 | Rutgers (4-6) | 12/4/2010 | W 35-14 |
| L 17-38 at | 11/27/2010 | Connecticut (6-5) | 10/29/2010 | L 13-16 1 at |
| L 10-28 | 12/4/2010 | Pittsburgh (7-4) | 11/26/2010 | W 35-10 at |
| 2-5 | 44-32 | 4-3 |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Western Carolina | 0-1 |
| L 19-30 at | 9/16/2010 | North Carolina State (7-4) | 9/4/2010 | L 7-48 at |
|
| 4-8 | — | 0 | (1 Common Ops) | 0 | Western Kentucky | 2-10 |
| L 30-38 | 10/22/2010 | South Florida (6-5) | 9/25/2010 | L 12-24 at |
|