| 0-1 | — | 0 | (1 Common Ops) | 0 | Boston College | 7-6 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 10/9/2010 | L 17-44 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Cincinnati | 4-8 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 9/16/2010 | L 19-30 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Clemson | 6-7 |
| L 7-48 at | 9/4/2010 | North Carolina State (8-3) | 11/6/2010 | W 14-13 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | East Carolina | 6-7 |
| L 7-48 at | 9/4/2010 | North Carolina State (8-3) | 10/16/2010 | W 33-27 1 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Florida State | 10-4 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 10/28/2010 | L 24-28 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Georgia Tech | 6-7 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 9/25/2010 | L 28-45 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Maryland | 9-4 |
| L 7-48 at | 9/4/2010 | North Carolina State (8-3) | 11/27/2010 | W 38-31 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | North Carolina | 8-5 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 11/20/2010 | L 25-29 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | UCF | 11-3 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 9/11/2010 | L 21-28 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Virginia Tech | 11-3 |
| L 7-48 at | 9/4/2010 | North Carolina State (8-3) | 10/2/2010 | W 41-30 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Wake Forest | 3-9 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 11/13/2010 | L 3-38 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | West Virginia | 9-4 |
| L 7-48 at | 9/4/2010 | North Carolina State (7-4) | 12/28/2010 | L 7-23 vs |
|