| 4-8 | — | 0 | (1 Common Ops) | 0 | Alabama | 9-3 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 10/16/2010 | W 23-10 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ark Pine Bluff | 0-1 |
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 9/4/2010 | L 10-31 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Arkansas | 10-3 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 10/23/2010 | W 38-24 | ||
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 11/13/2010 | W 58-21 | ||
| 1-1 | 9-12 | 2-0 | ||||
| 4-7 | — | 0 | (2 Common Ops) | 1 | Army | 6-6 |
| W 17-14 at | 10/2/2010 | Rutgers (3-7) | 10/16/2010 | L 20-23 1 vs | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 12/30/2010 | W 16-14 vs | ||
| 1-1 | 9-13 | 1-1 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Auburn | 14-0 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 10/30/2010 | W 51-31 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Baylor | 7-6 |
| W 54-49 | 11/13/2010 | Rice (4-6) | 9/25/2010 | W 30-13 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Bowling Green | 2-10 |
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 9/11/2010 | L 20-33 at | ||
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 9/18/2010 | W 44-28 | ||
| 0-2 | 12-9 | 1-1 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Buffalo | 2-10 |
| L 14-61 | 11/20/2010 | UCF (9-3) | 9/18/2010 | L 10-24 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | BYU | 7-6 |
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 12/18/2010 | W 52-24 vs | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Central Arkansas | 0-1 |
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 9/25/2010 | L 14-41 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Cincinnati | 4-8 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 11/20/2010 | W 69-38 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Connecticut | 8-5 |
| W 17-14 at | 10/2/2010 | Rutgers (3-7) | 10/8/2010 | L 24-27 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Duke | 3-9 |
| L 23-41 | 10/9/2010 | Army (5-6) | 9/25/2010 | L 21-35 | ||
| 4-8 | — | 0 | (6 Common Ops) | 0 | East Carolina | 6-7 |
| L 24-52 at | 10/16/2010 | Tulsa (9-2) | 9/5/2010 | W 51-49 | ||
| L 17-31 | 10/30/2010 | SMU (5-7) | 11/26/2010 | L 38-45 1 | ||
| L 30-46 | 11/6/2010 | Southern Miss (7-4) | 10/9/2010 | W 44-43 at | ||
| W 54-49 | 11/13/2010 | Rice (3-7) | 11/20/2010 | L 38-62 at | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 10/30/2010 | L 35-49 at | ||
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 10/23/2010 | W 37-10 | ||
| 1-5 | 37-29 | 3-3 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Eastern Michigan | 2-10 |
| L 23-41 | 10/9/2010 | Army (5-6) | 9/4/2010 | L 27-31 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Florida Intl | 7-6 |
| W 17-14 at | 10/2/2010 | Rutgers (3-7) | 9/11/2010 | L 14-19 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Fresno State | 8-5 |
| L 13-27 | 9/11/2010 | Mississippi (2-8) | 9/25/2010 | L 38-55 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Georgia | 6-7 |
| L 14-61 | 11/20/2010 | UCF (9-3) | 12/31/2010 | L 6-10 vs | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Hawaii | 10-4 |
| L 23-41 | 10/9/2010 | Army (6-5) | 9/11/2010 | W 31-28 at | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 12/24/2010 | L 35-62 vs | ||
| 0-2 | 14-8 | 1-1 | ||||
| 4-7 | — | 0 | (6 Common Ops) | 1 | Houston | 4-7 |
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 11/13/2010 | L 25-28 | ||
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 9/10/2010 | W 54-24 | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 10/23/2010 | W 45-20 at | ||
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 11/20/2010 | L 41-59 at | ||
| W 54-49 | 11/13/2010 | Rice (3-7) | 10/16/2010 | L 31-34 at | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 11/5/2010 | L 33-40 | ||
| 2-4 | 38-29 | 2-4 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Jacksonville State | 1-0 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 9/4/2010 | W 49-48 2 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kansas | 3-9 |
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 9/17/2010 | L 16-31 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kansas State | 7-6 |
| L 14-61 | 11/20/2010 | UCF (10-2) | 9/25/2010 | W 17-13 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| L 23-41 | 10/9/2010 | Army (5-6) | 11/13/2010 | L 28-45 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Kentucky | 6-7 |
| L 13-27 | 9/11/2010 | Mississippi (2-8) | 10/2/2010 | L 35-42 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Louisiana Tech | 5-7 |
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 9/25/2010 | L 12-13 | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Louisville | 7-6 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 11/26/2010 | W 40-13 at | ||
| L 30-46 | 11/6/2010 | Southern Miss (7-4) | 12/21/2010 | W 31-28 vs | ||
| 1-1 | 11-10 | 2-0 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | LSU | 11-2 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 11/20/2010 | W 43-36 | ||
| 4-7 | — | 0 | (4 Common Ops) | 1 | Marshall | 4-7 |
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 10/2/2010 | L 16-41 at | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 10/13/2010 | L 14-35 | ||
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 10/30/2010 | W 16-12 | ||
| L 17-31 | 10/30/2010 | SMU (5-7) | 11/20/2010 | L 17-31 at | ||
| 1-3 | 26-20 | 1-3 | ||||
| 4-8 | — | 0 | (6 Common Ops) | 0 | Memphis | 1-11 |
| L 23-42 at | 9/25/2010 | Houston (3-7) | 10/30/2010 | L 17-56 | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 10/2/2010 | L 7-48 | ||
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 9/25/2010 | L 13-16 at | ||
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 10/16/2010 | L 19-41 | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 11/27/2010 | L 17-37 | ||
| L 23-38 at | 11/27/2010 | Marshall (3-7) | 11/13/2010 | L 13-28 at | ||
| 1-5 | 34-31 | 0-6 | ||||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Mississippi State | 9-4 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 11/27/2010 | W 31-23 at | ||
| L 23-42 at | 9/25/2010 | Houston (4-6) | 10/9/2010 | W 47-24 at | ||
| 0-2 | 7-13 | 2-0 | ||||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Navy | 9-4 |
| L 23-41 | 10/9/2010 | Army (6-5) | 12/11/2010 | W 31-17 vs | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 10/16/2010 | W 28-21 | ||
| 0-2 | 12-11 | 2-0 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | New Mexico | 1-11 |
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 10/2/2010 | L 20-38 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | New Mexico State | 2-10 |
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 9/18/2010 | L 10-42 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Norfolk State | 0-1 |
| W 17-14 at | 10/2/2010 | Rutgers (3-7) | 9/2/2010 | L 0-31 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | North Carolina | 8-5 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 9/25/2010 | W 17-13 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | North Carolina State | 9-4 |
| L 14-61 | 11/20/2010 | UCF (10-2) | 9/11/2010 | W 28-21 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | North Texas | 3-9 |
| L 23-41 | 10/9/2010 | Army (5-6) | 9/18/2010 | L 0-24 at | ||
| W 54-49 | 11/13/2010 | Rice (3-7) | 9/11/2010 | L 31-32 | ||
| 1-1 | 8-13 | 0-2 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| W 54-49 | 11/13/2010 | Rice (4-6) | 9/18/2010 | W 30-13 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Notre Dame | 8-5 |
| L 23-41 | 10/9/2010 | Army (6-5) | 11/20/2010 | W 27-3 vs | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 10/30/2010 | L 27-28 | ||
| 0-2 | 14-8 | 1-1 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ohio | 8-5 |
| L 23-38 at | 11/27/2010 | Marshall (3-7) | 9/25/2010 | L 23-24 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 9/2/2010 | W 45-7 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Oklahoma State | 11-2 |
| L 24-52 at | 10/16/2010 | Tulsa (9-2) | 9/18/2010 | W 65-28 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Pittsburgh | 8-5 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 10/23/2010 | W 41-21 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Prairie View | 0-1 |
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 9/11/2010 | L 7-34 at | ||
| 3-8 | — | 1 | (5 Common Ops) | 0 | Rice | 4-7 |
| L 23-42 at | 9/25/2010 | Houston (4-6) | 10/16/2010 | W 34-31 | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 11/6/2010 | L 27-64 at | ||
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 10/9/2010 | L 24-44 at | ||
| L 17-31 | 10/30/2010 | SMU (5-7) | 10/2/2010 | L 31-42 | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 10/23/2010 | L 14-41 at | ||
| 1-4 | 31-25 | 1-4 | ||||
| 3-8 | — | 1 | (1 Common Ops) | 0 | Rutgers | 4-7 |
| L 23-41 | 10/9/2010 | Army (6-5) | 10/16/2010 | W 23-20 1 vs | ||
| 4-7 | — | 0 | (7 Common Ops) | 1 | SMU | 6-7 |
| L 23-42 at | 9/25/2010 | Houston (3-7) | 10/23/2010 | L 20-45 | ||
| L 23-41 | 10/9/2010 | Army (5-6) | 12/30/2010 | L 14-16 vs | ||
| L 24-52 at | 10/16/2010 | Tulsa (9-2) | 10/9/2010 | W 21-18 | ||
| W 34-24 at | 10/23/2010 | UTEP (5-6) | 11/6/2010 | L 14-28 at | ||
| W 54-49 | 11/13/2010 | Rice (4-6) | 10/2/2010 | W 42-31 at | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 12/4/2010 | L 7-17 at | ||
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 11/20/2010 | W 31-17 | ||
| 2-5 | 39-36 | 3-4 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Carolina | 9-5 |
| L 30-46 | 11/6/2010 | Southern Miss (7-4) | 9/2/2010 | W 41-13 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Dakota | 1-1 |
| L 14-61 | 11/20/2010 | UCF (9-3) | 9/4/2010 | L 7-38 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | South Florida | 8-5 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 11/3/2010 | W 28-27 | ||
| 4-7 | — | 0 | (4 Common Ops) | 1 | Southern Miss | 7-5 |
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 10/2/2010 | W 41-16 | ||
| L 14-61 | 11/20/2010 | UCF (10-2) | 11/13/2010 | W 31-21 at | ||
| L 23-42 at | 9/25/2010 | Houston (4-6) | 11/20/2010 | W 59-41 | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 11/26/2010 | L 50-56 at | ||
| 0-4 | 26-17 | 3-1 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 11/13/2010 | W 13-10 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | TCU | 13-0 |
| L 17-31 | 10/30/2010 | SMU (6-6) | 9/24/2010 | W 41-24 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Temple | 8-4 |
| L 23-41 | 10/9/2010 | Army (6-5) | 10/2/2010 | W 42-35 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Tennessee | 6-7 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 11/13/2010 | W 52-14 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas | 5-7 |
| W 54-49 | 11/13/2010 | Rice (4-6) | 9/4/2010 | W 34-17 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Texas State | 0-1 |
| L 23-42 at | 9/25/2010 | Houston (3-7) | 9/4/2010 | L 28-68 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | Texas Tech | 8-5 |
| L 23-42 at | 9/25/2010 | Houston (4-6) | 11/27/2010 | W 35-20 | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 9/5/2010 | W 35-27 | ||
| 0-2 | 10-12 | 2-0 | ||||
| 4-7 | — | 0 | (5 Common Ops) | 1 | Tulsa | 9-3 |
| L 23-42 at | 9/25/2010 | Houston (4-6) | 11/13/2010 | W 28-25 at | ||
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 11/20/2010 | W 31-28 | ||
| L 17-31 | 10/30/2010 | SMU (5-7) | 10/9/2010 | L 18-21 at | ||
| L 30-46 | 11/6/2010 | Southern Miss (7-4) | 11/26/2010 | W 56-50 | ||
| W 54-49 | 11/13/2010 | Rice (4-6) | 11/6/2010 | W 64-27 | ||
| 2-3 | 26-28 | 4-1 | ||||
| 4-8 | — | 0 | (6 Common Ops) | 0 | UAB | 4-8 |
| L 17-31 | 10/30/2010 | SMU (5-7) | 9/11/2010 | L 7-28 at | ||
| L 14-61 | 11/20/2010 | UCF (9-3) | 10/6/2010 | L 7-42 at | ||
| W 34-24 at | 10/23/2010 | UTEP (6-5) | 10/16/2010 | W 21-6 | ||
| L 30-46 | 11/6/2010 | Southern Miss (7-4) | 10/30/2010 | W 50-49 2 at | ||
| L 23-38 at | 11/27/2010 | Marshall (3-7) | 11/6/2010 | L 17-31 | ||
| W 54-49 | 11/13/2010 | Rice (3-7) | 11/27/2010 | L 23-28 at | ||
| 2-4 | 33-33 | 2-4 | ||||
| 4-7 | — | 0 | (5 Common Ops) | 1 | UCF | 10-3 |
| L 23-42 at | 9/25/2010 | Houston (4-6) | 11/5/2010 | W 40-33 at | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 12/4/2010 | W 17-7 | ||
| L 30-46 | 11/6/2010 | Southern Miss (6-5) | 11/13/2010 | L 21-31 | ||
| W 54-49 | 11/13/2010 | Rice (4-6) | 10/23/2010 | W 41-14 | ||
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 10/13/2010 | W 35-14 at | ||
| 1-4 | 24-29 | 4-1 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | UCLA | 4-8 |
| L 23-42 at | 9/25/2010 | Houston (4-6) | 9/18/2010 | W 31-13 | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | UL Lafayette | 3-9 |
| L 13-27 | 9/11/2010 | Mississippi (2-8) | 11/6/2010 | L 21-43 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | UL Monroe | 5-7 |
| W 27-21 | 9/2/2010 | Southeastern Louisiana (0-0) | 9/25/2010 | W 21-20 | ||
| 3-8 | — | 1 | (5 Common Ops) | 0 | UTEP | 6-6 |
| L 23-42 at | 9/25/2010 | Houston (3-7) | 9/10/2010 | L 24-54 at | ||
| L 24-52 at | 10/16/2010 | Tulsa (8-3) | 11/20/2010 | L 28-31 at | ||
| L 17-31 | 10/30/2010 | SMU (6-6) | 11/6/2010 | W 28-14 | ||
| W 54-49 | 11/13/2010 | Rice (4-6) | 10/9/2010 | W 44-24 | ||
| L 23-38 at | 11/27/2010 | Marshall (3-7) | 10/30/2010 | L 12-16 at | ||
| 1-4 | 24-29 | 2-3 | ||||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Vanderbilt | 2-10 |
| L 13-27 | 9/11/2010 | Mississippi (3-7) | 9/18/2010 | W 28-14 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | VMI | 0-2 |
| L 23-41 | 10/9/2010 | Army (5-6) | 10/30/2010 | L 7-29 at | ||
| 4-8 | — | 0 | (1 Common Ops) | 0 | Washington State | 2-10 |
| L 17-31 | 10/30/2010 | SMU (5-7) | 9/18/2010 | L 21-35 at | ||
| 4-8 | — | 0 | (2 Common Ops) | 0 | West Virginia | 9-4 |
| W 17-14 at | 10/2/2010 | Rutgers (4-6) | 12/4/2010 | W 35-14 | ||
| L 23-38 at | 11/27/2010 | Marshall (4-6) | 9/10/2010 | W 24-21 1 at | ||
| 1-1 | 8-12 | 2-0 | ||||