11 Jan 2011 5:04pm (US Central)
| 3-9 | — | 0 | (5 Common Ops) | 0 | Akron | 1-11 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 10/30/2010 | L 0-30 at |
| L 17-31 | 10/2/2010 | Ball State (2-8) | 11/6/2010 | L 30-37 2 at |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 11/17/2010 | L 14-19 |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 10/2/2010 | L 14-50 |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 10/23/2010 | L 10-56 |
| 1-4 | 30-24 | 0-5 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Arizona | 7-6 |
| L 31-42 at | 11/26/2010 | Toledo (7-4) | 9/3/2010 | W 41-2 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Arkansas State | 4-8 |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 11/20/2010 | L 19-35 at |
|
| 3-9 | — | 0 | (3 Common Ops) | 0 | Army | 7-6 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 10/2/2010 | L 35-42 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 9/4/2010 | W 31-27 at |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 12/11/2010 | L 17-31 vs |
| 1-2 | 15-16 | 1-2 |
|
| 3-8 | — | 0 | (4 Common Ops) | 1 | Ball State | 3-8 |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 10/9/2010 | L 16-45 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (1-9) | 10/16/2010 | L 38-41 1 |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 10/23/2010 | L 24-31 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 11/20/2010 | L 21-59 |
| 2-2 | 21-22 | 0-4 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Boise State | 12-1 |
| L 21-45 at | 10/9/2010 | Virginia Tech (10-2) | 9/6/2010 | W 33-30 vs |
| L 31-42 at | 11/26/2010 | Toledo (7-4) | 10/9/2010 | W 57-14 |
| 0-2 | 17-6 | 2-0 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Boston College | 7-6 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 9/25/2010 | L 0-19 |
|
| 3-8 | — | 0 | (4 Common Ops) | 1 | Bowling Green | 1-10 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 10/16/2010 | L 27-28 at |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 11/10/2010 | L 21-24 |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 11/26/2010 | L 7-41 |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 11/17/2010 | L 14-33 at |
| 1-3 | 25-18 | 0-4 |
|
| 3-9 | — | 0 | (6 Common Ops) | 0 | Buffalo | 2-10 |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 10/2/2010 | W 28-26 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 10/16/2010 | L 14-45 at |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 10/23/2010 | L 0-42 |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 10/30/2010 | L 9-21 |
| L 17-31 | 10/2/2010 | Ball State (2-8) | 11/12/2010 | L 3-20 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (1-9) | 11/20/2010 | L 17-21 |
| 1-5 | 27-37 | 1-5 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Cincinnati | 4-8 |
| L 20-27 | 10/16/2010 | Miami-Ohio (9-3) | 10/9/2010 | W 45-3 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Colorado State | 3-9 |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 9/18/2010 | L 10-31 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Connecticut | 8-5 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 9/18/2010 | L 16-30 at |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Duke | 3-9 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 10/23/2010 | L 7-44 at |
| L 37-38 at | 11/13/2010 | Navy (8-3) | 10/30/2010 | W 34-31 at |
| 0-2 | 17-6 | 1-1 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | East Carolina | 6-7 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 9/18/2010 | L 27-49 at |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 11/6/2010 | L 35-76 |
| 0-2 | 16-7 | 0-2 |
|
| 2-9 | — | 1 | (5 Common Ops) | 0 | Eastern Michigan | 2-9 |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 10/16/2010 | W 41-38 1 at |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 9/11/2010 | L 21-28 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 11/26/2010 | L 3-71 |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 11/13/2010 | L 30-45 at |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 10/30/2010 | L 7-42 |
| 1-4 | 31-24 | 1-4 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Florida | 8-5 |
| L 20-27 | 10/16/2010 | Miami-Ohio (9-3) | 9/4/2010 | W 34-12 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Florida Intl | 7-6 |
| L 31-42 at | 11/26/2010 | Toledo (7-4) | 12/26/2010 | W 34-32 vs |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Florida State | 10-4 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 12/4/2010 | L 33-44 vs |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Fresno State | 8-5 |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 12/18/2010 | L 17-40 vs |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Georgia Southern | 0-1 |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 9/11/2010 | L 7-13 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Georgia Tech | 6-7 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 11/4/2010 | L 21-28 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Idaho | 6-7 |
| W 26-22 | 11/5/2010 | Western Michigan (6-4) | 10/2/2010 | W 33-13 at |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Illinois | 7-6 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 11/20/2010 | W 48-27 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (10-2) | 9/18/2010 | W 28-22 |
| 0-2 | 16-7 | 2-0 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Illinois State | 0-1 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 9/11/2010 | L 3-37 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 10/30/2010 | L 17-20 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Iowa | 8-5 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 11/13/2010 | L 17-21 at |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 9/25/2010 | W 45-0 |
| 0-2 | 8-13 | 1-1 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Iowa State | 5-7 |
| L 7-33 at | 10/23/2010 | Northern Illinois (10-2) | 9/2/2010 | W 27-10 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | James Madison | 1-0 |
| L 21-45 at | 10/9/2010 | Virginia Tech (10-2) | 9/11/2010 | W 21-16 at |
|
| 3-9 | — | 0 | (6 Common Ops) | 0 | Kent State | 5-7 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 11/6/2010 | L 10-28 |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 10/30/2010 | W 33-14 |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 10/2/2010 | L 21-27 at |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 10/23/2010 | W 30-6 at |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 11/20/2010 | L 3-38 at |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 10/16/2010 | L 21-34 at |
| 1-5 | 29-34 | 2-4 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Liberty | 1-0 |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 9/11/2010 | W 27-23 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Louisiana Tech | 5-7 |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 9/18/2010 | L 23-37 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Marshall | 5-7 |
| L 14-17 | 10/30/2010 | Bowling Green (0-10) | 9/18/2010 | L 28-44 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Maryland | 9-4 |
| L 37-38 at | 11/13/2010 | Navy (8-3) | 9/6/2010 | W 17-14 vs |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Miami-Florida | 7-6 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 11/20/2010 | L 17-31 |
|
| 3-8 | — | 0 | (4 Common Ops) | 1 | Miami-Ohio | 9-4 |
| L 10-13 1 at | 9/9/2010 | Temple (7-3) | 11/23/2010 | W 23-3 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 9/11/2010 | W 28-21 |
| L 7-33 at | 10/23/2010 | Northern Illinois (10-2) | 12/3/2010 | W 26-21 vs |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 11/10/2010 | W 24-21 at |
| 1-3 | 20-22 | 4-0 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 9/25/2010 | W 65-21 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Michigan State | 11-2 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 10/23/2010 | W 35-27 at |
| W 26-22 | 11/5/2010 | Western Michigan (6-4) | 9/4/2010 | W 38-14 |
| 1-1 | 12-9 | 2-0 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Middle Tenn State | 6-7 |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 1/6/2011 | L 21-35 vs |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Minnesota | 3-9 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 10/2/2010 | L 28-29 |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 9/25/2010 | L 23-34 |
| 0-2 | 14-9 | 0-2 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Missouri | 10-3 |
| L 20-27 | 10/16/2010 | Miami-Ohio (9-3) | 9/25/2010 | W 51-13 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Nicholls State | 0-2 |
| W 26-22 | 11/5/2010 | Western Michigan (5-5) | 9/11/2010 | L 14-49 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | North Carolina | 8-5 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 11/13/2010 | L 10-26 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | North Carolina State | 9-4 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 10/2/2010 | L 30-41 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | North Dakota | 0-2 |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 9/11/2010 | L 17-23 at |
|
| 3-8 | — | 0 | (6 Common Ops) | 1 | Northern Illinois | 10-3 |
| L 10-13 1 at | 9/9/2010 | Temple (7-3) | 10/9/2010 | W 31-17 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 11/26/2010 | W 71-3 at |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 11/20/2010 | W 59-21 at |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 12/3/2010 | L 21-26 vs |
| W 26-22 | 11/5/2010 | Western Michigan (6-4) | 10/30/2010 | W 28-21 at |
| L 31-42 at | 11/26/2010 | Toledo (7-4) | 11/9/2010 | W 65-30 |
| 2-4 | 33-30 | 5-1 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Notre Dame | 8-5 |
| W 26-22 | 11/5/2010 | Western Michigan (6-4) | 10/16/2010 | W 44-20 |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 10/23/2010 | L 17-35 vs |
| 1-1 | 13-8 | 1-1 |
|
| 3-9 | — | 0 | (5 Common Ops) | 0 | Ohio | 8-5 |
| L 10-13 1 at | 9/9/2010 | Temple (7-3) | 11/16/2010 | W 31-23 at |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 10/2/2010 | W 30-17 at |
| L 20-27 | 10/16/2010 | Miami-Ohio (9-3) | 10/23/2010 | W 34-13 at |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 10/9/2010 | W 49-25 |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 9/11/2010 | L 13-20 |
| 1-4 | 25-28 | 4-1 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 9/25/2010 | W 73-20 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Penn State | 7-6 |
| L 10-13 1 at | 9/9/2010 | Temple (7-3) | 9/25/2010 | W 22-13 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 11/6/2010 | W 35-21 |
| 0-2 | 13-8 | 2-0 |
|
| 3-9 | — | 0 | (3 Common Ops) | 0 | Purdue | 4-8 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 10/9/2010 | W 20-17 at |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 9/18/2010 | W 24-13 |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 9/25/2010 | L 20-31 |
| 0-3 | 15-17 | 2-1 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Rice | 4-8 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 9/18/2010 | L 13-30 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | San Diego State | 9-4 |
| L 37-38 at | 11/13/2010 | Navy (8-3) | 12/23/2010 | W 35-14 vs |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | SE Missouri State | 0-1 |
| L 17-31 | 10/2/2010 | Ball State (2-8) | 9/2/2010 | L 10-27 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | SMU | 7-7 |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 10/16/2010 | L 21-28 at |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Stanford | 12-1 |
| L 21-45 at | 10/9/2010 | Virginia Tech (10-2) | 1/3/2011 | W 40-12 vs |
|
| 3-8 | — | 0 | (3 Common Ops) | 1 | Temple | 7-4 |
| L 20-27 | 10/16/2010 | Miami-Ohio (8-4) | 11/23/2010 | L 3-23 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 10/9/2010 | L 17-31 at |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 10/16/2010 | W 28-27 |
| 0-3 | 18-16 | 1-2 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Texas Tech | 8-5 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 1/1/2011 | W 45-38 vs |
|
| 3-8 | — | 0 | (5 Common Ops) | 1 | Toledo | 7-5 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 10/30/2010 | W 42-7 at |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 10/23/2010 | W 31-24 |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 11/9/2010 | L 30-65 at |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 11/17/2010 | W 33-14 |
| W 26-22 | 11/5/2010 | Western Michigan (6-4) | 9/18/2010 | W 37-24 at |
| 2-3 | 21-31 | 4-1 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Troy | 8-5 |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 9/4/2010 | W 30-27 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Tulsa | 10-3 |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 9/11/2010 | W 33-20 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Vanderbilt | 2-10 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 10/9/2010 | W 52-6 |
| L 25-30 at | 9/25/2010 | Northwestern (5-6) | 9/4/2010 | L 21-23 |
| 1-1 | 7-14 | 1-1 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Villanova | 0-1 |
| L 10-13 1 at | 9/9/2010 | Temple (6-4) | 9/3/2010 | L 24-31 at |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Virginia | 4-8 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 10/23/2010 | W 48-21 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 11/27/2010 | L 7-37 at |
| 1-1 | 11-11 | 1-1 |
|
| 3-9 | — | 0 | (2 Common Ops) | 0 | Wake Forest | 3-9 |
| L 21-45 at | 10/9/2010 | Virginia Tech (9-3) | 10/16/2010 | L 21-52 at |
| L 37-38 at | 11/13/2010 | Navy (7-4) | 10/9/2010 | L 27-28 |
| 0-2 | 16-7 | 0-2 |
|
| 2-9 | — | 1 | (5 Common Ops) | 0 | Western Michigan | 6-5 |
| W 52-14 at | 9/18/2010 | Eastern Michigan (2-8) | 11/13/2010 | W 45-30 |
| L 17-31 | 10/2/2010 | Ball State (3-7) | 10/9/2010 | W 45-16 at |
| L 7-33 at | 10/23/2010 | Northern Illinois (9-3) | 10/30/2010 | L 21-28 |
| L 14-17 | 10/30/2010 | Bowling Green (1-9) | 11/26/2010 | W 41-7 at |
| L 31-42 at | 11/26/2010 | Toledo (6-5) | 9/18/2010 | L 24-37 |
| 1-4 | 21-32 | 3-2 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| L 25-30 at | 9/25/2010 | Northwestern (6-5) | 11/27/2010 | W 70-23 |
|
| 3-9 | — | 0 | (1 Common Ops) | 0 | Wyoming | 3-9 |
| L 31-42 at | 11/26/2010 | Toledo (7-4) | 10/2/2010 | W 20-15 at |
|