| 9/4/2021 | Savannah State (8-2) | 7 | at | Valdosta State | 53 | SIAC | ||
| 9/11/2021 | Valdosta State | 51 | at | Virginia Union (6-4) | 7 | at CIAA | ||
| 9/18/2021 | Albany State GA (10-2) | 3 | at | Valdosta State | 21 | SIAC | ||
| 10/2/2021 | Shorter (3-8,0-7) | 13 | at | Valdosta State | 49 | |||
| 10/9/2021 | Delta State (5-6,3-5) | 0 | at | Valdosta State | 55 | |||
| 10/16/2021 | Valdosta State | 42 | at | West Alabama (7-4,4-4) | 17 | |||
| 10/23/2021 | Valdosta State | 41 | at | Mississippi College (4-6,3-5) | 14 | |||
| 10/30/2021 | West Georgia (9-3,6-3) | 34 | at | Valdosta State | 36 | |||
| 11/6/2021 | North Greenville (5-6,2-5) | 21 | at | Valdosta State | 31 | |||
| 11/13/2021 | Valdosta State | 42 | at | West Florida (9-2,6-1) | 61 | |||
| 11/27/2021 | West Georgia (9-3,6-3) | 35 | at | Valdosta State | 66 | |||
| 12/4/2021 | Bowie State (12-2) | 17 | at | Valdosta State | 41 | CIAA | ||
| 12/11/2021 | Colorado Mines (12-2) | 31 | at | Valdosta State | 34 | D2 Semifinal | RMAC | |
| 12/18/2021 | Valdosta State | 17 | vs | Ferris State (14-0) | 58 | D2 Championship - McKinney TX | vs GLIAC |
| vs Valdosta State | vs Other Opponents | Valdosta State compared to OOs | |
| Record: | 2-12 | 111-36 | |
| Points Scored: | 22.71 | 34.07 | 11.36 |
| Points Allowed: | 41.36 | 19.16 | 22.20 |
| Margin: | -18.65 | 14.91 | 33.56 |
| Total Points: | 64.07 | 53.23 | 10.84 |