| 9/2/2021 | Findlay (8-4) | 14 | at | Ferris State | 54 | GMAC | ||
| 9/11/2021 | Ferris State | 45 | at | Ashland (5-5) | 19 | at GMAC | ||
| 9/18/2021 | Saginaw Valley State (7-4,5-3) | 45 | at | Ferris State | 47 | OT | ||
| 9/25/2021 | Davenport (3-8,2-7) | 0 | at | Ferris State | 38 | |||
| 10/2/2021 | Ferris State | 67 | at | Northwood (1-9,1-7) | 25 | |||
| 10/16/2021 | Ferris State | 35 | at | Grand Valley State (10-2,7-2) | 28 | |||
| 10/23/2021 | Ferris State | 38 | at | Michigan Tech (6-4,5-3) | 10 | |||
| 10/30/2021 | Northern Michigan (4-7,3-6) | 24 | at | Ferris State | 44 | |||
| 11/6/2021 | Ferris State | 50 | at | Davenport (3-8,2-7) | 14 | |||
| 11/13/2021 | Wayne State MI (2-9,2-6) | 13 | at | Ferris State | 35 | |||
| 11/27/2021 | Grand Valley State (10-2,7-2) | 20 | at | Ferris State | 54 | |||
| 12/4/2021 | Northwest Missouri State (11-2) | 20 | at | Ferris State | 41 | MAIAA | ||
| 12/11/2021 | Shepherd (13-2) | 7 | at | Ferris State | 55 | D2 Semifinal | PSAC | |
| 12/18/2021 | Valdosta State (12-2) | 17 | vs | Ferris State | 58 | D2 Championship - McKinney TX | GSC |
| vs Ferris State | vs Other Opponents | Ferris State compared to OOs | |
| Record: | 0-14 | 95-50 | |
| Points Scored: | 18.29 | 30.46 | 12.17 |
| Points Allowed: | 47.21 | 22.58 | 24.63 |
| Margin: | -28.92 | 7.88 | 36.80 |
| Total Points: | 65.50 | 53.04 | 12.46 |