| 9/2/2021 | West Georgia | 45 | at | Carson-Newman (1-9) | 7 | at SAC | ||
| 9/11/2021 | Morehouse (4-6) | 0 | at | West Georgia | 47 | SIAC | ||
| 9/18/2021 | Delta State (5-6,3-5) | 26 | at | West Georgia | 27 | |||
| 9/25/2021 | West Georgia | 56 | at | Shorter (3-8,0-7) | 0 | |||
| 10/2/2021 | West Alabama (7-4,4-4) | 38 | at | West Georgia | 20 | |||
| 10/9/2021 | West Georgia | 40 | at | Mississippi College (4-6,3-5) | 21 | |||
| 10/16/2021 | West Georgia | 30 | at | West Florida (9-2,6-1) | 26 | |||
| 10/23/2021 | North Greenville (5-6,2-5) | 12 | at | West Georgia | 34 | |||
| 10/30/2021 | West Georgia | 34 | at | Valdosta State (12-2,7-1) | 36 | |||
| 11/13/2021 | Delta State (5-6,3-5) | 7 | at | West Georgia | 44 | |||
| 11/20/2021 | West Georgia | 23 | at | Albany State GA (10-2) | 7 | at SIAC | ||
| 11/27/2021 | West Georgia | 35 | at | Valdosta State (12-2,7-1) | 66 |
| vs West Georgia | vs Other Opponents | West Georgia compared to OOs | |
| Record: | 3-9 | 72-48 | |
| Points Scored: | 20.50 | 31.30 | 10.80 |
| Points Allowed: | 36.25 | 25.05 | 11.20 |
| Margin: | -15.75 | 6.25 | 22.00 |
| Total Points: | 56.75 | 56.35 | 0.40 |