| 9/2/2021 | Albany State GA | 24 | at | Mississippi College (4-6) | 0 | at GSC | ||
| 9/11/2021 | Shorter (3-8) | 12 | at | Albany State GA | 28 | GSC | ||
| 9/18/2021 | Albany State GA | 3 | at | Valdosta State (12-2) | 21 | at GSC | ||
| 9/25/2021 | Clark Atlanta (2-8,1-7) | 0 | at | Albany State GA | 49 | |||
| 10/2/2021 | Albany State GA | 31 | at | Miles (6-5,6-3) | 3 | |||
| 10/9/2021 | Edward Waters (4-7,3-7) | 0 | at | Albany State GA | 30 | |||
| 10/16/2021 | Albany State GA | 28 | at | Benedict (5-5,5-5) | 6 | |||
| 10/23/2021 | Savannah State (8-2,6-1) | 0 | at | Albany State GA | 30 | |||
| 10/30/2021 | Albany State GA | 14 | at | Morehouse (4-6,4-4) | 10 | |||
| 11/6/2021 | Albany State GA | 57 | vs | Fort Valley State (5-5,5-4) | 0 | Columbus GA | ||
| 11/13/2021 | Albany State GA | 31 | at | Miles (6-5,6-3) | 0 | |||
| 11/20/2021 | West Georgia (9-3) | 23 | at | Albany State GA | 7 | GSC |
| vs Albany State GA | vs Other Opponents | Albany State GA compared to OOs | |
| Record: | 2-10 | 66-50 | |
| Points Scored: | 6.25 | 28.61 | 22.36 |
| Points Allowed: | 27.67 | 25.16 | 2.51 |
| Margin: | -21.42 | 3.45 | 24.87 |
| Total Points: | 33.92 | 53.77 | -19.85 |