| 9/2/2021 | Bethel TN (7-4) | 14 | at | Delta State | 48 | MSC (NAIA) | ||
| 9/11/2021 | McKendree (4-7) | 17 | at | Delta State | 45 | GLV | ||
| 9/18/2021 | Delta State | 26 | at | West Georgia (9-3,6-3) | 27 | |||
| 9/25/2021 | Delta State | 17 | at | Jackson State (11-2) | 24 | at SWAC | ||
| 10/2/2021 | West Florida (9-2,6-1) | 39 | at | Delta State | 33 | |||
| 10/9/2021 | Delta State | 0 | at | Valdosta State (12-2,7-1) | 55 | |||
| 10/16/2021 | North Greenville (5-6,2-5) | 42 | at | Delta State | 34 | 2OT | ||
| 10/23/2021 | Delta State | 35 | at | West Alabama (7-4,4-4) | 30 | |||
| 10/30/2021 | Shorter (3-8,0-7) | 13 | at | Delta State | 14 | |||
| 11/6/2021 | Mississippi College (4-6,3-5) | 21 | at | Delta State | 24 | OT | ||
| 11/13/2021 | Delta State | 7 | at | West Georgia (9-3,6-3) | 44 |
| vs Delta State | vs Other Opponents | Delta State compared to OOs | |
| Record: | 6-5 | 72-42 | |
| Points Scored: | 29.64 | 33.22 | 3.58 |
| Points Allowed: | 25.73 | 25.03 | 0.70 |
| Margin: | 3.91 | 8.19 | 4.28 |
| Total Points: | 55.37 | 58.25 | -2.88 |