| 9/4/2021 | Limestone (0-9) | 16 | at | North Greenville | 37 | SAC | ||
| 9/11/2021 | North Greenville | 24 | at | Newberry (10-3) | 14 | at SAC | ||
| 9/18/2021 | North Greenville | 13 | at | The Citadel (4-7) | 45 | at SoCon | ||
| 9/25/2021 | North Greenville | 38 | at | Erskine (3-8) | 7 | at D2Ind | ||
| 10/2/2021 | Mississippi College (4-6,3-5) | 42 | at | North Greenville | 21 | |||
| 10/9/2021 | West Florida (9-2,6-1) | 52 | at | North Greenville | 10 | |||
| 10/16/2021 | North Greenville | 42 | at | Delta State (5-6,3-5) | 34 | 2OT | ||
| 10/23/2021 | North Greenville | 12 | at | West Georgia (9-3,6-3) | 34 | |||
| 10/30/2021 | West Alabama (7-4,4-4) | 31 | at | North Greenville | 14 | |||
| 11/6/2021 | North Greenville | 21 | at | Valdosta State (12-2,7-1) | 31 | |||
| 11/13/2021 | Shorter (3-8,0-7) | 0 | at | North Greenville | 56 |
| vs North Greenville | vs Other Opponents | North Greenville compared to OOs | |
| Record: | 6-5 | 60-53 | |
| Points Scored: | 27.82 | 29.62 | 1.80 |
| Points Allowed: | 26.18 | 26.96 | -0.78 |
| Margin: | 1.64 | 2.66 | 1.02 |
| Total Points: | 54.00 | 56.58 | -2.58 |