| 9/4/2021 | Bowie State | 24 | at | Delaware State (5-6) | 32 | at MEAC | ||
| 9/11/2021 | Saginaw Valley State (7-4) | 19 | at | Bowie State | 28 | GLIAC | ||
| 9/18/2021 | Bowie State | 27 | at | New Haven (10-2) | 13 | at NE10 | ||
| 9/25/2021 | Bowie State | 49 | at | Livingstone (1-8,1-5) | 0 | |||
| 10/2/2021 | Johnson C Smith (1-7,1-5) | 7 | at | Bowie State | 44 | |||
| 10/9/2021 | Bowie State | 14 | at | Chowan (7-3,4-3) | 3 | |||
| 10/16/2021 | Virginia State (3-6,3-4) | 44 | at | Bowie State | 51 | |||
| 10/23/2021 | Bowie State | 27 | at | Virginia Union (6-4,5-2) | 7 | |||
| 10/30/2021 | Bowie State | 31 | at | Lincoln PA (1-9,1-6) | 7 | |||
| 11/6/2021 | Elizabeth City State (3-7,3-5) | 6 | at | Bowie State | 79 | |||
| 11/13/2021 | Bowie State | 17 | at | Fayetteville State (8-2,8-1) | 7 | |||
| 11/20/2021 | Lenoir-Rhyne (8-3) | 10 | at | Bowie State | 31 | SAC | ||
| 11/27/2021 | Newberry (10-3) | 10 | at | Bowie State | 13 | SAC | ||
| 12/4/2021 | Bowie State | 17 | at | Valdosta State (12-2) | 41 | at GSC |
| vs Bowie State | vs Other Opponents | Bowie State compared to OOs | |
| Record: | 2-12 | 80-54 | |
| Points Scored: | 14.71 | 27.66 | 12.95 |
| Points Allowed: | 32.29 | 21.83 | 10.46 |
| Margin: | -17.58 | 5.83 | 23.41 |
| Total Points: | 47.00 | 49.49 | -2.49 |