| 8/28/2010 | Chowan 10 @ Lenoir-Rhyne Bears 59 | |
| 9/4/2010 | Chowan 14 @ The Citadel Bulldogs 56 | |
| 9/18/2010 | Chowan 7 @ Winston-Salem State Rams 48 | † |
| 9/25/2010 | Virginia State Trojans 20 @ Chowan 13 | † |
| 10/2/2010 | Virginia Union Panthers 34 @ Chowan 35 | † |
| 10/9/2010 | Lincoln PA Lions 27 @ Chowan 30 | † |
| 10/16/2010 | Chowan 31 @ St Paul's Fighting Tigers 20 | † |
| 10/23/2010 | Chowan 14 @ Shaw Bears 35 | † |
| 10/30/2010 | Chowan 7 @ Elizabeth City State Vikings 55 | † |
| 11/6/2010 | Bowie State Bulldogs 59 @ Chowan 19 | † |