| 8/28/2010 | Virginia Union 13 vs Winston-Salem State Rams 47 (High Point NC) | † |
| 9/4/2010 | Virginia Union 27 @ Shaw Bears 57 | † |
| 9/18/2010 | Lincoln PA Lions 31 @ Virginia Union 55 | † |
| 9/25/2010 | Virginia Union 27 @ Bowie State Bulldogs 28 | † |
| 10/2/2010 | Virginia Union 34 @ Chowan Braves 35 | † |
| 10/9/2010 | Virginia Union 14 @ Elizabeth City State Vikings 17 | † |
| 10/16/2010 | Johnson C Smith Golden Bulls 21 @ Virginia Union 44 | † |
| 10/23/2010 | St Paul's Fighting Tigers 28 @ Virginia Union 39 | † |
| 10/30/2010 | Virginia State Trojans 35 @ Virginia Union 7 | † |
| 11/6/2010 | Virginia Union 28 @ Fayetteville State Broncos 44 | † |