| 9/4/2010 | St Augustine's 20 @ Catawba Indians 17 | |
| 9/11/2010 | Mars Hill Lions 41 @ St Augustine's 12 | |
| 9/18/2010 | St Paul's Fighting Tigers 7 @ St Augustine's 31 | † |
| 9/25/2010 | St Augustine's 52 @ Lincoln PA Lions 21 | † |
| 10/2/2010 | Fayetteville State Broncos 36 @ St Augustine's 42 | † |
| 10/9/2010 | St Augustine's 40 @ Winston-Salem State Rams 35 | † |
| 10/16/2010 | St Augustine's 21 @ Central State Marauders 14 | |
| 10/23/2010 | St Augustine's 34 @ Johnson C Smith Golden Bulls 24 | † |
| 10/30/2010 | St Augustine's 33 @ Livingstone Blue Bears 0 | † |
| 11/6/2010 | Shaw Bears 10 @ St Augustine's 6 | † |
| 12/4/2010 | St Augustine's 20 @ Fort Valley State Wildcats 9 |