| 9/4/2010 | Haskell Indians 0 @ McPherson 45 | |
| 9/11/2010 | McPherson 52 @ Friends Falcons 20 | † |
| 9/18/2010 | Ottawa Braves 24 @ McPherson 56 | † |
| 10/2/2010 | McPherson 31 @ Sterling Warriors 21 | † |
| 10/9/2010 | St Mary KS Spires 24 @ McPherson 73 | † |
| 10/16/2010 | Kansas Wesleyan Coyotes 42 @ McPherson 56 | † |
| 10/23/2010 | McPherson 55 @ Southwestern Moundbuilders 21 | † |
| 10/30/2010 | Tabor Bluejays 14 @ McPherson 40 | † |
| 11/6/2010 | Bethel KS Threshers 0 @ McPherson 47 | † |
| 11/13/2010 | McPherson 52 @ Bethany KS Terrible Swedes 35 | † |
| 11/20/2010 | McKendree Bearcats 38 @ McPherson 14 |