| 9/4/2010 | Rhodes 17 @ Westminster MO Blue Jays 20 | |
| 9/11/2010 | Washington U Bears 10 @ Rhodes 14 | |
| 9/18/2010 | Rhodes 22 @ Trinity TX Tigers 16 | † |
| 10/2/2010 | LaGrange Panthers 42 @ Rhodes 28 | |
| 10/9/2010 | Rhodes 18 @ DePauw Tigers 42 | † |
| 10/16/2010 | Millsaps Majors 70 @ Rhodes 31 | † |
| 10/24/2010 | Rhodes 16 @ Austin Kangaroos 17 | † |
| 10/30/2010 | Centre Praying Colonels 31 @ Rhodes 38 | † |
| 11/6/2010 | Birmingham-Southern Panthers 41 @ Rhodes 19 | † |
| 11/13/2010 | Rhodes 20 @ Sewanee Tigers 16 | † |