| 9/4/2010 | LaGrange Panthers 19 @ Birmingham-Southern 28 | |
| 9/11/2010 | Birmingham-Southern 52 @ Faulkner Eagles 16 | |
| 9/25/2010 | Birmingham-Southern 35 @ Huntingdon AL Hawks 20 | |
| 10/2/2010 | Trinity TX Tigers 38 @ Birmingham-Southern 28 | † |
| 10/9/2010 | Birmingham-Southern 28 @ Centre Praying Colonels 35 | † |
| 10/16/2010 | Austin Kangaroos 21 @ Birmingham-Southern 44 | † |
| 10/23/2010 | Sewanee Tigers 10 @ Birmingham-Southern 50 | † |
| 10/30/2010 | Birmingham-Southern 23 @ DePauw Tigers 30 | † |
| 11/6/2010 | Birmingham-Southern 41 @ Rhodes Lynx 19 | † |
| 11/13/2010 | Millsaps Majors 28 @ Birmingham-Southern 17 | † |