| 9/4/2010 | Worcester Polytechnic 3 @ Salve Regina Seahawks 6 | |
| 9/11/2010 | Worcester State Lancers 20 @ Worcester Polytechnic 27 1OT | |
| 9/18/2010 | Becker Hawks 0 @ Worcester Polytechnic 55 | |
| 9/25/2010 | Worcester Polytechnic 24 @ Rensselaer Engineers 10 | † |
| 10/2/2010 | Union NY Dutchmen 25 @ Worcester Polytechnic 17 | † |
| 10/9/2010 | Worcester Polytechnic 9 @ Merchant Marine Mariners 26 | † |
| 10/23/2010 | Rochester Yellow Jackets 16 @ Worcester Polytechnic 15 | † |
| 10/30/2010 | Worcester Polytechnic 13 @ Hobart Statesmen 38 | † |
| 11/6/2010 | Susquehanna Crusaders 14 @ Worcester Polytechnic 7 | |
| 11/13/2010 | Worcester Polytechnic 7 @ St Lawrence Saints 27 | † |