| 9/11/2010 | Case Western Reserve Spartans 14 @ Rochester 10 | |
| 9/18/2010 | Rochester 21 vs St John Fisher Cardinals 49 (Rochester NY) | |
| 9/25/2010 | Rochester 14 @ Union NY Dutchmen 16 | † |
| 10/2/2010 | Rensselaer Engineers 17 @ Rochester 0 | † |
| 10/16/2010 | Merchant Marine Mariners 48 @ Rochester 19 | † |
| 10/23/2010 | Rochester 16 @ Worcester Polytechnic Engineers 15 | † |
| 10/30/2010 | Rochester 24 @ Alfred Saxons 14 | |
| 11/6/2010 | St Lawrence Saints 7 @ Rochester 34 | † |
| 11/13/2010 | Rochester 35 @ Hobart Statesmen 34 | † |