| 9/11/2010 | Dickinson Red Devils 7 @ Hobart 38 | |
| 9/18/2010 | Hobart 35 @ Carnegie Mellon Tartans 21 | |
| 9/25/2010 | St John Fisher Cardinals 34 @ Hobart 14 | |
| 10/2/2010 | Hobart 21 @ St Lawrence Saints 24 | † |
| 10/9/2010 | Union NY Dutchmen 35 @ Hobart 41 2OT | † |
| 10/23/2010 | Hobart 40 @ Merchant Marine Mariners 33 | † |
| 10/30/2010 | Worcester Polytechnic Engineers 13 @ Hobart 38 | † |
| 11/6/2010 | Hobart 21 @ Rensselaer Engineers 24 | † |
| 11/13/2010 | Rochester Yellow Jackets 35 @ Hobart 34 | † |