| 9/11/2010 | Rensselaer 6 @ Endicott Power Gulls 3 | |
| 9/18/2010 | Rensselaer 21 @ Utica Pioneers 42 | |
| 9/25/2010 | Worcester Polytechnic Engineers 24 @ Rensselaer 10 | † |
| 10/2/2010 | Rensselaer 17 @ Rochester Yellow Jackets 0 | † |
| 10/16/2010 | Alfred Saxons 24 @ Rensselaer 27 | |
| 10/23/2010 | Rensselaer 3 @ St Lawrence Saints 14 | † |
| 10/30/2010 | Union NY Dutchmen 7 @ Rensselaer 21 | † |
| 11/6/2010 | Hobart Statesmen 21 @ Rensselaer 24 | † |
| 11/13/2010 | Rensselaer 29 @ Merchant Marine Mariners 27 | † |
| 11/20/2010 | Rensselaer 13 @ St John Fisher Cardinals 56 (ECAC Northwest Bowl) |