| 9/4/2010 | Anna Maria Amcats 21 @ Worcester State 49 | |
| 9/11/2010 | Worcester State 20 @ Worcester Polytechnic Engineers 27 1OT | |
| 9/17/2010 | Worcester State 32 @ Nichols Bison 29 | † |
| 9/25/2010 | Westfield State Owls 18 @ Worcester State 30 | † |
| 10/2/2010 | Worcester State 32 @ Maine Maritime Mariners 61 | † |
| 10/9/2010 | Massachusetts Maritime Buccaneers 21 @ Worcester State 13 | † |
| 10/16/2010 | Worcester State 9 @ Bridgewater State MA Bears 25 | † |
| 10/23/2010 | Coast Guard Bears 7 @ Worcester State 31 | † |
| 10/30/2010 | Fitchburg State Falcons 6 @ Worcester State 41 | † |
| 11/6/2010 | Worcester State 21 @ Framingham State Rams 42 | † |