| 9/4/2010 | Gallaudet Bison 34 @ Merchant Marine 35 | |
| 9/11/2010 | Merchant Marine 8 @ Coast Guard Bears 10 | |
| 9/18/2010 | Merchant Marine 34 @ SUNY-Maritime Privateers 41 | |
| 9/25/2010 | St Lawrence Saints 13 @ Merchant Marine 6 | † |
| 10/2/2010 | Merchant Marine 0 @ Springfield Pride 64 | |
| 10/9/2010 | Worcester Polytechnic Engineers 9 @ Merchant Marine 26 | † |
| 10/16/2010 | Merchant Marine 48 @ Rochester Yellow Jackets 19 | † |
| 10/23/2010 | Hobart Statesmen 40 @ Merchant Marine 33 | † |
| 11/6/2010 | Merchant Marine 28 @ Union NY Dutchmen 21 | † |
| 11/13/2010 | Rensselaer Engineers 29 @ Merchant Marine 27 | † |